Understanding genetic changes in skin cancer progression
PQ3 Cutaneous squamous cell carcinoma: Integrating germline and somatic alterations that underlie tumor progression
This study is looking at how certain genetic changes in skin cancer can help us understand why it spreads and how to find better treatments, and we’re inviting patients to share their genetic samples and health information to help with this important research.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10836131 on NIH RePORTER |
What this research studies
This research investigates cutaneous squamous cell carcinoma (cSCC), a common skin cancer, by analyzing genetic alterations that contribute to its progression and metastasis. The team will integrate data on both tumor mutations and genetic risk factors from patients to identify potential targets for new treatments. By studying a large cohort of cSCC cases, the research aims to fill gaps in knowledge that have hindered the development of effective therapies. Patients may be asked to provide genetic samples and clinical information to support this important work.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with cutaneous squamous cell carcinoma, particularly those with advanced or metastatic disease.
Not a fit: Patients with other types of skin cancer or those without a diagnosis of cutaneous squamous cell carcinoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies that improve treatment outcomes for patients with cSCC.
How similar studies have performed: Previous research efforts, such as The Cancer Genome Atlas, have successfully identified genetic alterations in other cancers, suggesting that this approach could yield valuable insights for cSCC as well.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Asgari, Maryam Mandana — University of Colorado Denver
- Study coordinator: Asgari, Maryam Mandana
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.