Understanding the genetic changes in skin cancer
The genomic landscape and evolution of cutaneous squamous cell carcinoma
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-11064287
This study is looking at how certain genetic changes in skin cells can lead to squamous cell carcinoma, a type of skin cancer, by comparing cancerous spots with their non-cancerous beginnings, to help find better ways to catch and treat this cancer early for patients like you.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-11064287 on ClinicalTrials.gov |
What this research studies
This research investigates cutaneous squamous cell carcinoma, a type of skin cancer, by analyzing the genetic mutations that drive its development. The team will collect and analyze genetic data from both cancerous lesions and their benign precursors, known as actinic keratoses, to understand how these mutations evolve over time. By sequencing the genomes of these lesions, the researchers aim to identify key mutations that lead to cancer, potentially improving early detection and treatment strategies for patients. This comprehensive approach will utilize both existing data and new samples to create the largest dataset of its kind.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with cutaneous squamous cell carcinoma or those with actinic keratoses.
Not a fit: Patients with other types of skin cancer or those without any skin lesions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic tools and targeted therapies for patients with cutaneous squamous cell carcinoma.
How similar studies have performed: Previous research has shown promise in understanding genetic mutations in other cancers, suggesting that this approach could yield valuable insights for cutaneous squamous cell carcinoma as well.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHAIN, ALAN HUNTER — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: SHAIN, ALAN HUNTER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.