New topical cream to treat precancerous skin lesions and prevent skin cancer.
Official title: Investigational new drug enabling studies for the development of a topical fixed dose combination drug product to treat actinic keratosis and prevent cutaneous squamous cell carcinoma.
Funded at Phd Skin Care LLC · NIH-10701001 · Data updated 2026-11-12
This study is testing a new cream that combines two medicines to help treat actinic keratosis and lower the chances of getting skin cancer, and it's designed for people who want a more effective and easy-to-use treatment for these skin issues.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Phd Skin Care LLC NIH-funded |
| Lab location | 1 site (La Jolla, UNITED STATES) |
| Project start | September 15, 2022 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $865,339 |
| NIH project number | 5R44AR080475-02 |
| Project ID | NIH-10701001 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with actinic keratosis who are at risk of developing cutaneous squamous cell carcinoma.
✕Less likely to help
Patients who do not have actinic keratosis or those with advanced skin cancer may not benefit from this research.
What this research studies
This research focuses on developing a new topical cream that combines two medications, calcipotriol and 5-fluorouracil, to treat actinic keratosis (AK) and prevent cutaneous squamous cell carcinoma (CSCC). The approach aims to harness the immune system's response to effectively manage these skin conditions. Patients will apply this cream, which is designed to be stable and well-tolerated, potentially offering a more effective treatment option than existing therapies. The goal is to provide a prescription product that not only treats AK but also reduces the risk of developing skin cancer.
Why it matters
Potential benefit: If successful, this research could provide patients with a more effective treatment for actinic keratosis and significantly lower their risk of developing skin cancer.
How similar studies have gone: Previous studies have shown promise in using similar combination therapies for skin conditions, indicating potential for success in this innovative approach.
Where this research is happening
-
Phd Skin Care LLC
La Jolla, United States Active
Researchers
- Principal investigator: Mahon, Andrew B — Phd Skin Care LLC
- Study coordinator: Mahon, Andrew B
Related research
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This study is looking at how a specific gene might affect the development of skin cancer, especially in military personnel who are often exposed to the sun, with the hope of finding new ways to treat this common condition.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.