Transcatheter device to relieve heart failure by lowering left atrial pressure
Official title: Transcatheter Device for Congestive Heart Failure Treatment Through Left Atrial Decompression
Funded at Alleviant Medical, INC. · NIH-11289343 · Data updated 2026-11-12
A new catheter-based device aims to help people with chronic heart failure by creating a small passage between the left and right atria to lower left atrial pressure and ease symptoms.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Alleviant Medical, INC. NIH-funded |
| Lab location | 1 site (Austin, UNITED STATES) |
| Project start | September 1, 2018 |
| Project end | February 28, 2027 |
| Funding year | 2026 |
| Award (this year) | $996,173 |
| NIH project number | 5R44HL142440-06 |
| Project ID | NIH-11289343 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with chronic heart failure, particularly those with HFpEF or HFmrEF, who may be candidates for interatrial shunt therapy.
✕Less likely to help
Patients without suitable anatomy or those who do not meet device eligibility criteria may not benefit.
What this research studies
This project explores a minimally invasive device that may improve daily living for people with chronic heart failure, especially those who have limited options. The team is studying an implant approach that could reduce the pressure in the left atrium and potentially lessen hospitalizations. Results from this work could inform how interatrial shunting might fit into treatment for patients with preserved or mid-range ejection fraction heart failure. The research is being conducted at a company-affiliated center with a focus on translating device concepts into clinical options for patients.
Why it matters
Potential benefit: If successful, patients with CHF could experience symptom relief and possibly fewer hospital visits.
How similar studies have gone: Prior studies have shown that interatrial shunting devices can lower left atrial pressure and improve symptoms in some patients, but results vary by patient group.
Where this research is happening
-
Alleviant Medical, INC.
Austin, United States Active
Researchers
- Principal investigator: Pate, Thomas Diffley — Alleviant Medical, INC.
- Study coordinator: Pate, Thomas Diffley
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.