Investigating blood proteins related to heart damage and failure

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to determine if two specific proteins, cleaved caspase-3 and dystrophin, are elevated in the blood during acute myocardial infarction and whether their levels differ between individuals who develop heart failure and those who do not. The study will involve measuring these proteins in patients diagnosed with acute myocardial infarction, as well as in a control group of older men without heart disease. The findings could provide insights into the biological processes involved in heart damage and failure.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* men and women, 18 years of age and over with acute myocardial infarction (determined by positive cardiac markers -CKMB/ troponin) with or without heart failure (dyspnea, rales, edema, elevated jugular venous pressure, ascites).
* Heart failure can be diagnosed using imaging evidence such as dilated heart, poor contractile function or echocardiographic Doppler evidence of diastolic dysfunction or elevated right- or left-sided filling pressures
* A control group of male subjects age 60 and older without history of MI or heart disease

Exclusion Criteria:

* Subjects unable to give consent
* Subjects who have undergone cardiac or non-cardiac surgery in the 3 months prior to enrollment

Where it's running

• University of Connecticut Health Center
  Farmington, Connecticut, United States Recruiting

Study contacts

• Principal investigator: Bruce T. Liang, MD — UConn Health
• Study coordinator: Kristen Siedlarz, MA
• Email: siedlarz@uchc.edu
• Phone: 860-679-7549

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.