Fever clinic tracking of acute respiratory infections
The Fever Clinic Acute Respiratory Cohort (FACTS): A Prospective Real-World Cohort Study of Patients Presenting to Fever Clinics: Clinical Features, Laboratory and Radiographic Findings, and Long-Term Outcomes of Acute Respiratory Infections
This project follows adults who come to a fever clinic with respiratory infections to see how their symptoms, test results, and outcomes change over time.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1000 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Fudan University Academic / other |
| Locations | 1 site (Shanghai, Shanghai Municipality) |
| Trial ID | NCT07278700 on ClinicalTrials.gov |
What this trial studies
This prospective cohort enrolls adults presenting to a fever clinic with fever judged by their doctor to be caused by a respiratory infection. At enrollment the team collects clinical symptoms, laboratory parameters, chest imaging, and routine blood samples. Participants are followed over time to document disease progression, complications, treatments received, and longer-term outcomes. No experimental interventions are given and all care is provided by the treating physicians, allowing capture of real-world clinical course and factors linked to outcomes.
Who should consider this trial
Good fit: Adults (≥18 years) who present to the participating fever clinic with documented fever within 24 hours and whose attending physician determines the fever is primarily due to a respiratory infection, who can provide informed consent and undergo blood sampling as part of care.
Not a fit: People who cannot give independent informed consent, have contraindications to blood draws, have a non-respiratory cause of fever, or have a terminal illness with life expectancy under three months are unlikely to benefit from participation.
Why it matters
Potential benefit: If successful, the findings could help clinicians identify patients at higher risk of complications and improve triage, testing, and treatment decisions in fever clinics.
How similar studies have performed: Previous observational cohorts of influenza and other respiratory infections have successfully identified risk factors and informed care, so this fever-clinic cohort builds on established methods rather than being wholly novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 18 years (based on official identification document). * Presence of fever at the time of visit or within 24 hours prior to the visit, defined as a documented temperature of ≥37.3°C axillary/tympanic, ≥37.8°C orally, or ≥38.0°C rectally. * The primary cause of fever, as determined by the attending physician, is a respiratory tract infection. * Blood draw is required as part of standard clinical care. * Ability to comprehend the study's purpose, procedures, and potential risks, and willingness to provide written informed consent. Exclusion Criteria: * Inability to provide independent informed consent due to impaired consciousness or other reasons. * Inability to comply with the study procedures. * Medical contraindications to blood sampling, such as severe coagulopathy (e.g., INR \> 3.0, platelet count \< 50 × 10⁹/L). * Diagnosed with a terminal illness (e.g., advanced malignancy, severe multiple organ failure) and a life expectancy of less than 3 months.
Where this trial is running
Shanghai, Shanghai Municipality
- Huadong hospital — Shanghai, Shanghai Municipality, China (Recruiting)
Study contacts
- Study coordinator: YingGang Zhu, Doctor
- Email: robinzyg@gmail.com
- Phone: +8618001637153
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.