Fever clinic tracking of acute respiratory infections
Official title: The Fever Clinic Acute Respiratory Cohort (FACTS): A Prospective Real-World Cohort Study of Patients Presenting to Fever Clinics: Clinical Features, Laboratory and Radiographic Findings, and Long-Term Outcomes of Acute Respiratory Infections
Run by Fudan University · NCT07278700 · Data updated 2026-11-12
This project follows adults who come to a fever clinic with respiratory infections to see how their symptoms, test results, and outcomes change over time.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 1000 (estimated) |
| Sponsor | Fudan University Academic / other |
| Locations | 1 site (Shanghai, Shanghai Municipality) |
| Status | Recruiting |
| Started | October 10, 2025 |
| Main results expected | October 2028 |
| Study ends | October 2028 |
| Registry record updated | December 12, 2025 |
| Trial ID | NCT07278700 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (≥18 years) who present to the participating fever clinic with documented fever within 24 hours and whose attending physician determines the fever is primarily due to a respiratory infection, who can provide informed consent and undergo blood sampling as part of care.
✕Probably not a fit
People who cannot give independent informed consent, have contraindications to blood draws, have a non-respiratory cause of fever, or have a terminal illness with life expectancy under three months are unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This prospective cohort enrolls adults presenting to a fever clinic with fever judged by their doctor to be caused by a respiratory infection. At enrollment the team collects clinical symptoms, laboratory parameters, chest imaging, and routine blood samples. Participants are followed over time to document disease progression, complications, treatments received, and longer-term outcomes. No experimental interventions are given and all care is provided by the treating physicians, allowing capture of real-world clinical course and factors linked to outcomes.
Why it matters
Potential benefit: If successful, the findings could help clinicians identify patients at higher risk of complications and improve triage, testing, and treatment decisions in fever clinics.
How similar studies have gone: Previous observational cohorts of influenza and other respiratory infections have successfully identified risk factors and informed care, so this fever-clinic cohort builds on established methods rather than being wholly novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 18 years (based on official identification document). * Presence of fever at the time of visit or within 24 hours prior to the visit, defined as a documented temperature of ≥37.3°C axillary/tympanic, ≥37.8°C orally, or ≥38.0°C rectally. * The primary cause of fever, as determined by the attending physician, is a respiratory tract infection. * Blood draw is required as part of standard clinical care. * Ability to comprehend the study's purpose, procedures, and potential risks, and willingness to provide written informed consent. Exclusion Criteria: * Inability to provide independent informed consent due to impaired consciousness or other reasons. * Inability to comply with the study procedures. * Medical contraindications to blood sampling, such as severe coagulopathy (e.g., INR \> 3.0, platelet count \< 50 × 10⁹/L). * Diagnosed with a terminal illness (e.g., advanced malignancy, severe multiple organ failure) and a life expectancy of less than 3 months.
Where it's running
-
Huadong hospital
Shanghai, Shanghai Municipality, China Recruiting
Study contacts
- Study coordinator: YingGang Zhu, Doctor
- Email: robinzyg@gmail.com
- Phone: +8618001637153
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.