Targeted antibiotic treatment for community-acquired pneumonia
Official title: Reducing Antimicrobial Overuse Through Targeted Therapy for Patients with Community-Acquired Pneumonia
Funded at Cleveland Clinic Foundation · NIH-11161399 · Data updated 2026-11-12
This project uses faster diagnostic tests to help doctors pick and shorten antibiotics for adults hospitalized with community-acquired pneumonia.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Foundation NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | September 30, 2021 |
| Project end | August 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $500,000 |
| NIH project number | 5R01HS028633-05 |
| Project ID | NIH-11161399 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults hospitalized with community-acquired pneumonia, especially those started on broad-spectrum empiric antibiotics, are the intended participants.
✕Less likely to help
People with hospital-acquired or ventilator-associated pneumonia, children, or those treated entirely as outpatients are unlikely to be eligible or benefit.
What this research studies
From a patient's perspective, doctors will use rapid molecular tests on respiratory samples to try to identify the germ causing your pneumonia within hours instead of days. When a pathogen is found or tests are negative, clinicians can start narrower antibiotics or stop broad-spectrum drugs sooner. The project will track antibiotic duration, safety, and recovery to see how faster results change care. The aim is to reduce unnecessary antibiotic exposure while keeping patients safe.
Why it matters
Potential benefit: Could lower exposure to broad-spectrum antibiotics, reducing side effects and the chance of antibiotic resistance.
How similar studies have gone: Multiple observational studies have linked rapid molecular diagnostics to shorter antibiotic courses, though randomized evidence is still limited.
Where this research is happening
-
Cleveland Clinic Foundation
Cleveland, United States Active
Researchers
- Principal investigator: Rothberg, Michael B — Cleveland Clinic Foundation
- Study coordinator: Rothberg, Michael B
Related research
Other NIH-funded projects on the same topics.
-
Improving treatment for pneumonia by using targeted therapies
This study is looking at how to better identify the germs that cause community-acquired pneumonia so that patients can get the right antibiotics quickly, helping them recover faster and reducing the chances of antibiotic resistance.
-
Azithromycin vs doxycycline with beta-lactam in hospitalized adults with pneumonia
In hospitalized adults with community-acquired pneumonia, this study will compare two antibiotic combinations to see which works better and is safer.
-
Combined immunomodulatory effect of macrolides and corticosteroids in hospitalized CAP patients
This study looks at whether adding macrolide antibiotics to steroids helps or harms people hospitalized with community-acquired pneumonia (CAP).
-
Blocking ANGPTL4 to help people with severe community-acquired pneumonia
This project will test whether blocking the blood protein ANGPTL4 helps adults hospitalized with severe community-acquired pneumonia recover faster and survive more often.
-
Pediatric pneumonia severity score (PedCAPS)
This project will create and check a simple score to predict how serious pneumonia will be in children who come to the emergency room.
-
Ketogenic diet to help muscle in older adults with pneumonia
A small trial will test if a short 10-day ketogenic (low carb, high fat) feeding helps preserve muscle and speed recovery in people 65 and older hospitalized with pneumonia.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.