Targeted antibiotic treatment for community-acquired pneumonia
Reducing Antimicrobial Overuse Through Targeted Therapy for Patients with Community-Acquired Pneumonia
This project uses faster diagnostic tests to help doctors pick and shorten antibiotics for adults hospitalized with community-acquired pneumonia.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Foundation NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11161399 on NIH RePORTER |
What this research studies
From a patient's perspective, doctors will use rapid molecular tests on respiratory samples to try to identify the germ causing your pneumonia within hours instead of days. When a pathogen is found or tests are negative, clinicians can start narrower antibiotics or stop broad-spectrum drugs sooner. The project will track antibiotic duration, safety, and recovery to see how faster results change care. The aim is to reduce unnecessary antibiotic exposure while keeping patients safe.
Who could benefit from this research
Good fit: Adults hospitalized with community-acquired pneumonia, especially those started on broad-spectrum empiric antibiotics, are the intended participants.
Not a fit: People with hospital-acquired or ventilator-associated pneumonia, children, or those treated entirely as outpatients are unlikely to be eligible or benefit.
Why it matters
Potential benefit: Could lower exposure to broad-spectrum antibiotics, reducing side effects and the chance of antibiotic resistance.
How similar studies have performed: Multiple observational studies have linked rapid molecular diagnostics to shorter antibiotic courses, though randomized evidence is still limited.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Foundation — Cleveland, United States (Active)
Researchers
- Principal investigator: Rothberg, Michael B — Cleveland Clinic Foundation
- Study coordinator: Rothberg, Michael B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.