Understanding long-term effects of Gram-negative pneumonia
Official title: Determinants of long-term outcomes and heterogeneity in Gram-negative community-acquired pneumonia
Funded at University of Washington · NIH-10899457 · Data updated 2026-11-12
This study is looking at how people who have survived a serious lung infection called pneumonia, caused by a specific germ, do over time after leaving the hospital, and it aims to find out what factors might lead to health problems later on so that doctors can provide better care for those who need it.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $94,528 |
| NIH project number | 5F32HL168809-02 |
| Project ID | NIH-10899457 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have been hospitalized with community-acquired pneumonia caused by Burkholderia pseudomallei.
✕Less likely to help
Patients with pneumonia caused by other pathogens or those who have not been hospitalized may not benefit from this research.
What this research studies
This research investigates the long-term health outcomes of patients who have survived community-acquired pneumonia (CAP) caused by the Gram-negative bacterium Burkholderia pseudomallei. It aims to identify the factors that contribute to adverse outcomes after hospital discharge, focusing on the immune response and the severity of the illness at admission. By analyzing a large group of patients in Northeast Thailand, the study seeks to uncover biological markers and subgroups of patients that may require different treatment approaches. This could lead to better-targeted therapies for those affected by this serious infection.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies and better long-term health outcomes for patients recovering from Gram-negative pneumonia.
How similar studies have gone: Previous research has shown that understanding the immune response in pneumonia can lead to better outcomes, suggesting this approach has potential for success.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Coston, Taylor David — University of Washington
- Study coordinator: Coston, Taylor David
Related research
Other NIH-funded projects on the same topics.
-
Azithromycin vs doxycycline with beta-lactam in hospitalized adults with pneumonia
In hospitalized adults with community-acquired pneumonia, this study will compare two antibiotic combinations to see which works better and is safer.
-
Combined immunomodulatory effect of macrolides and corticosteroids in hospitalized CAP patients
This study looks at whether adding macrolide antibiotics to steroids helps or harms people hospitalized with community-acquired pneumonia (CAP).
-
Blocking ANGPTL4 to help people with severe community-acquired pneumonia
This project will test whether blocking the blood protein ANGPTL4 helps adults hospitalized with severe community-acquired pneumonia recover faster and survive more often.
-
Pediatric pneumonia severity score (PedCAPS)
This project will create and check a simple score to predict how serious pneumonia will be in children who come to the emergency room.
-
Ketogenic diet to help muscle in older adults with pneumonia
A small trial will test if a short 10-day ketogenic (low carb, high fat) feeding helps preserve muscle and speed recovery in people 65 and older hospitalized with pneumonia.
-
Using systems biology to understand severe community-acquired pneumonia
This project analyzes patients' lung and blood samples with advanced lab tests and computer models to find biological patterns that can help guide treatment for people with severe pneumonia, including COVID-related cases.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.