Comparing two flu vaccines for older adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study evaluates the effectiveness of two types of influenza vaccines, the quadrivalent adjuvanted inactivated influenza vaccine (aIIV4) and the quadrivalent high-dose inactivated influenza vaccine (HD-IIV4), in preventing confirmed influenza and related health outcomes in adults aged 65 and older. Conducted at Kaiser Permanente Northern California, the study will analyze data from the 2023/24 and 2024/25 influenza seasons. Participants will be KPNC members who receive one of the vaccines at a KPNC facility during the specified seasons.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥65 years at the time of influenza vaccination
* KPNC member at the time of vaccination
* Receive either aIIV4 or HD-IIV4 at a KPNC facility during the 2023/24 and/or 2024/25 influenza seasons

Exclusion Criteria:

* Age \<65 years at the time of influenza vaccination
* Received either aIIV4 or HD-IIV4 in the inpatient setting
* Receive more than one influenza vaccination during a single season period (i.e., 2023/24 or 2024/25 influenza seasons)
* Receive an influenza vaccination outside of KPNC

Where it's running

• Kaiser Permanente Northern California (entire region)
  Oakland, California, United States Recruiting

Study contacts

• Study coordinator: Amber H. Hyman, PhD, MPH
• Email: Amber.Hyman@kp.org
• Phone: 510-267-7571

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.