Modeling severe pneumonia caused by the coronavirus
Systems Biology Modeling of Severe Community-Acquired Pneumonia
This study is looking at how severe pneumonia caused by the coronavirus affects patients, using samples from their lungs to find ways to better predict their recovery and improve treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11014081 on NIH RePORTER |
What this research studies
This research investigates severe community-acquired pneumonia (CAP) linked to the coronavirus SARS-CoV-2 by collecting and analyzing respiratory samples from patients. It employs advanced multi-omics techniques and machine learning to understand how patients transition through different clinical states during their hospitalization. The goal is to develop a comprehensive model that can predict patient outcomes and improve treatment strategies for severe pneumonia. By leveraging extensive clinical data, the research aims to identify biomarkers and therapeutic targets that could enhance patient care.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with severe community-acquired pneumonia, particularly those requiring mechanical ventilation.
Not a fit: Patients with mild pneumonia or those not infected with SARS-CoV-2 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment protocols and reduced mortality rates for patients suffering from severe pneumonia.
How similar studies have performed: Previous research has shown success in using systems biology approaches to understand pneumonia and improve treatment outcomes, indicating a promising avenue for this study.
Where this research is happening
Chicago, United States
- Northwestern University at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Wunderink, Richard G — Northwestern University at Chicago
- Study coordinator: Wunderink, Richard G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.