Improving treatment for pneumonia by using targeted therapies
Reducing Antimicrobial Overuse Through Targeted Therapy for Patients with Community-Acquired Pneumonia
This study is looking at how to better identify the germs that cause community-acquired pneumonia so that patients can get the right antibiotics quickly, helping them recover faster and reducing the chances of antibiotic resistance.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Foundation NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10906059 on NIH RePORTER |
What this research studies
This research focuses on community-acquired pneumonia (CAP), a common cause of hospitalizations. It aims to enhance the accuracy of diagnosing the pathogens responsible for CAP, which is often challenging due to negative culture results. By utilizing rapid diagnostic tests, the study seeks to promote the use of narrow-spectrum antibiotics, reducing unnecessary broad-spectrum therapy and minimizing the risk of antibiotic resistance. This approach not only aims to improve patient outcomes but also supports better antimicrobial stewardship.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with community-acquired pneumonia who may benefit from targeted antimicrobial therapy.
Not a fit: Patients with pneumonia caused by pathogens that are not detectable by the rapid diagnostic assays may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and safer treatment options for patients with pneumonia, reducing the risk of antibiotic resistance.
How similar studies have performed: Previous observational studies have shown that molecular diagnostic assays can lead to favorable outcomes, indicating that this approach has potential based on existing evidence.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Foundation — Cleveland, United States (Active)
Researchers
- Principal investigator: Rothberg, Michael B — Cleveland Clinic Foundation
- Study coordinator: Rothberg, Michael B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.