Improving treatment for pneumonia by using targeted therapies
Official title: Reducing Antimicrobial Overuse Through Targeted Therapy for Patients with Community-Acquired Pneumonia
Funded at Cleveland Clinic Foundation · NIH-10906059 · Data updated 2026-11-12
This study is looking at how to better identify the germs that cause community-acquired pneumonia so that patients can get the right antibiotics quickly, helping them recover faster and reducing the chances of antibiotic resistance.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Foundation NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | September 30, 2021 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $500,000 |
| NIH project number | 5R01HS028633-04 |
| Project ID | NIH-10906059 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with community-acquired pneumonia who may benefit from targeted antimicrobial therapy.
✕Less likely to help
Patients with pneumonia caused by pathogens that are not detectable by the rapid diagnostic assays may not benefit from this research.
What this research studies
This research focuses on community-acquired pneumonia (CAP), a common cause of hospitalizations. It aims to enhance the accuracy of diagnosing the pathogens responsible for CAP, which is often challenging due to negative culture results. By utilizing rapid diagnostic tests, the study seeks to promote the use of narrow-spectrum antibiotics, reducing unnecessary broad-spectrum therapy and minimizing the risk of antibiotic resistance. This approach not only aims to improve patient outcomes but also supports better antimicrobial stewardship.
Why it matters
Potential benefit: If successful, this research could lead to more effective and safer treatment options for patients with pneumonia, reducing the risk of antibiotic resistance.
How similar studies have gone: Previous observational studies have shown that molecular diagnostic assays can lead to favorable outcomes, indicating that this approach has potential based on existing evidence.
Where this research is happening
-
Cleveland Clinic Foundation
Cleveland, United States Active
Researchers
- Principal investigator: Rothberg, Michael B — Cleveland Clinic Foundation
- Study coordinator: Rothberg, Michael B
Related research
Other NIH-funded projects on the same topics.
-
Targeted antibiotic treatment for community-acquired pneumonia
This project uses faster diagnostic tests to help doctors pick and shorten antibiotics for adults hospitalized with community-acquired pneumonia.
-
Azithromycin vs doxycycline with beta-lactam in hospitalized adults with pneumonia
In hospitalized adults with community-acquired pneumonia, this study will compare two antibiotic combinations to see which works better and is safer.
-
Combined immunomodulatory effect of macrolides and corticosteroids in hospitalized CAP patients
This study looks at whether adding macrolide antibiotics to steroids helps or harms people hospitalized with community-acquired pneumonia (CAP).
-
Blocking ANGPTL4 to help people with severe community-acquired pneumonia
This project will test whether blocking the blood protein ANGPTL4 helps adults hospitalized with severe community-acquired pneumonia recover faster and survive more often.
-
Pediatric pneumonia severity score (PedCAPS)
This project will create and check a simple score to predict how serious pneumonia will be in children who come to the emergency room.
-
Ketogenic diet to help muscle in older adults with pneumonia
A small trial will test if a short 10-day ketogenic (low carb, high fat) feeding helps preserve muscle and speed recovery in people 65 and older hospitalized with pneumonia.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.