Investigating the role of ANGPTL4 in severe pneumonia outcomes
Targeting Angiopoietin-like 4 (ANGPTL4) in Severe Community Acquired Pneumonia
This study is looking at how a protein called ANGPTL4 might influence how well patients with severe pneumonia recover, and it aims to find better ways to help them heal.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11047089 on NIH RePORTER |
What this research studies
This research focuses on understanding how the protein ANGPTL4 affects the outcomes of patients suffering from severe community-acquired pneumonia (CAP). By analyzing blood samples from patients, the study aims to identify how variations in ANGPTL4 levels correlate with recovery and complications. The research includes both observational data from patient cohorts and preclinical studies in animal models to explore potential therapeutic interventions targeting ANGPTL4. Ultimately, the goal is to find ways to improve patient care and outcomes for those hospitalized with severe pneumonia.
Who could benefit from this research
Good fit: Ideal candidates for this research are hospitalized patients diagnosed with severe community-acquired pneumonia.
Not a fit: Patients with mild pneumonia or those not requiring hospitalization may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve recovery rates and reduce mortality in patients with severe pneumonia.
How similar studies have performed: Other research has shown promising results in targeting ANGPTL4 for improving outcomes in severe pneumonia, indicating that this approach has potential based on previous findings.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Bhatraju, Pavan Kumar — University of Washington
- Study coordinator: Bhatraju, Pavan Kumar
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.