Investigating the role of ANGPTL4 in severe pneumonia outcomes
Official title: Targeting Angiopoietin-like 4 (ANGPTL4) in Severe Community Acquired Pneumonia
Funded at University of Washington · NIH-11047089 · Data updated 2026-11-12
This study is looking at how a protein called ANGPTL4 might influence how well patients with severe pneumonia recover, and it aims to find better ways to help them heal.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | April 4, 2025 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $827,909 |
| NIH project number | 1R01HL172872-01A1 |
| Project ID | NIH-11047089 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are hospitalized patients diagnosed with severe community-acquired pneumonia.
✕Less likely to help
Patients with mild pneumonia or those not requiring hospitalization may not benefit from this research.
What this research studies
This research focuses on understanding how the protein ANGPTL4 affects the outcomes of patients suffering from severe community-acquired pneumonia (CAP). By analyzing blood samples from patients, the study aims to identify how variations in ANGPTL4 levels correlate with recovery and complications. The research includes both observational data from patient cohorts and preclinical studies in animal models to explore potential therapeutic interventions targeting ANGPTL4. Ultimately, the goal is to find ways to improve patient care and outcomes for those hospitalized with severe pneumonia.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve recovery rates and reduce mortality in patients with severe pneumonia.
How similar studies have gone: Other research has shown promising results in targeting ANGPTL4 for improving outcomes in severe pneumonia, indicating that this approach has potential based on previous findings.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Bhatraju, Pavan Kumar — University of Washington
- Study coordinator: Bhatraju, Pavan Kumar
Related research
Other NIH-funded projects on the same topics.
-
Azithromycin vs doxycycline with beta-lactam in hospitalized adults with pneumonia
In hospitalized adults with community-acquired pneumonia, this study will compare two antibiotic combinations to see which works better and is safer.
-
Combined immunomodulatory effect of macrolides and corticosteroids in hospitalized CAP patients
This study looks at whether adding macrolide antibiotics to steroids helps or harms people hospitalized with community-acquired pneumonia (CAP).
-
Blocking ANGPTL4 to help people with severe community-acquired pneumonia
This project will test whether blocking the blood protein ANGPTL4 helps adults hospitalized with severe community-acquired pneumonia recover faster and survive more often.
-
Pediatric pneumonia severity score (PedCAPS)
This project will create and check a simple score to predict how serious pneumonia will be in children who come to the emergency room.
-
Ketogenic diet to help muscle in older adults with pneumonia
A small trial will test if a short 10-day ketogenic (low carb, high fat) feeding helps preserve muscle and speed recovery in people 65 and older hospitalized with pneumonia.
-
Using systems biology to understand severe community-acquired pneumonia
This project analyzes patients' lung and blood samples with advanced lab tests and computer models to find biological patterns that can help guide treatment for people with severe pneumonia, including COVID-related cases.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.