Condition

Chronic Migraine Headache clinical trials and research

• 13Clinical trials
• 17Countries

Newest Chronic Migraine Headache clinical trials

All recruiting trials (13)

• MySalvia System for Resistant Migraine: a minimally invasive implant to prevent migraines

  This study tests whether the MySalvia System, a small implant that stimulates nerves, can prevent migraines in adults with resistant or chronic migraine.

  Recruiting at 3 sites Salvia BioElectronics · Newnan, Georgia and 2 other locations · NCT07719608

• MMA Embolization for Migraine: Patient-Reported Outcomes from a Single Site

  This registry tests whether adults with migraine who have or plan to have middle meningeal artery embolization notice changes in headaches and quality of life over time.

  Recruiting Cortex Neurovascular · Tacoma, Washington · NCT07652034

• What Makes People with Chronic Migraine Susceptible to Suggestion and How It Relates to Placebo

  We’re testing how suggestibility relates to placebo response in adults with chronic migraine who don’t respond to standard treatments.

  Recruiting Istituto per la Ricerca e l'Innovazione Biomedica · Catanzaro, Catanzaro · NCT07617441

• Ultrasound-Guided Nerve Block High-Voltage PRF for Chronic Migraine

  This study tests whether a higher-voltage pulsed radiofrequency treatment applied to the sphenopalatine ganglion under ultrasound guidance can help adults with chronic migraine who haven’t had enough relief from other preventives.

  Recruiting at 2 sites Minia University · Minya and 1 other locations · NCT07500558

• Myofascial trigger point steroid injection versus greater occipital nerve block for chronic migraine

  This trial will test whether steroid injections into myofascial trigger points work as well as greater occipital nerve block for adults (18–65) with chronic migraine who still have moderate pain despite treatment.

  Recruiting Beijing Tiantan Hospital · Beijing, Beijing Municipality · NCT07347067

• Bilateral middle meningeal artery embolization for refractory chronic migraine

  This study will try blocking both middle meningeal arteries with Onyx in adults who have refractory bilateral chronic migraine to see if it is safe and lowers headaches.

  Recruiting Johns Hopkins University · Baltimore, Maryland · NCT07223008

• Real-world use of anti-CGRP medicines for preventing migraine

  This project will follow people with episodic or chronic migraine who start anti-CGRP medicines to see if the treatments reduce migraine frequency and side effects over two years.

  Recruiting at 25 sites Hospital Universitari Vall d'Hebron Research Institute · Miami, Florida and 25 other locations · NCT07159750

• New methods to test preventive migraine treatment

  This trial will test how the active medicine, placebo injections, and the information given about them affect symptoms in adults with chronic migraine.

  Recruiting at 2 sites University of Aarhus · Aarhus C, Denmark and 1 other locations · NCT07071506

• Nordic comparison of CGRP antibody plus onabotulinumtoxinA (Botox) versus CGRP antibody alone for chronic migraine

  This trial will test whether adding onabotulinumtoxinA (Botox) to a CGRP monoclonal antibody reduces monthly headache days in adults with chronic migraine.

  Recruiting Phase 3 Oslo University Hospital · Grålum and 5 other locations · NCT07040813

• Embolization of the middle meningeal artery for chronic resistant migraine treatment

  This study is testing a new procedure to block a specific artery in the brain to see if it can help people with chronic migraines who haven't found relief from other treatments.

  Recruiting Vedanta University Clinic · Bishkek, Bishkek · NCT06848166

• Comparing nerve block injections to Botox for chronic migraine relief

  This study tests whether nerve block injections or Botox can help adults with chronic migraines feel better and have fewer migraine days.

  Recruiting Zagazig University · Zagazig, Sharqia Province · NCT06684249

• Analyzing CGRP Levels in Migraine Patients by Age and Sex

  This study looks at the levels of a substance linked to migraines in people with migraines and healthy individuals to see how age and sex might affect treatment responses.

  Recruiting Hospital Universitari Vall d'Hebron Research Institute · Barcelona, Barcelona · NCT06674772

• Analyzing CGRP Levels in Migraine Patients by Age and Sex

  This study looks at the levels of a substance linked to migraines in people with migraines and healthy individuals to see how age and sex might affect treatment responses.

  Recruiting Hospital Universitari Vall d'Hebron Research Institute · Barcelona, Barcelona · NCT06674772

Related topics

Quick answers

How many Chronic Migraine Headache clinical trials are recruiting right now?

13, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 17 countries. The most sites are in United States (4 trials), Spain (3 trials), Italy (2 trials), Egypt (2 trials), Norway (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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