Investigating the role of a specific receptor in chronic migraine
Official title: The involvement of GPR37L1 on a chronic migraine-like state
Funded at Florida Atlantic University · NIH-10845955 · Data updated 2026-11-12
This study is looking at how a specific receptor in the brain might play a role in chronic migraines, using animal models to see what happens when this receptor is missing, with the hope of finding new ways to help people who suffer from migraines.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida Atlantic University NIH-funded |
| Lab location | 1 site (Boca Raton, United States) |
| Project start | July 10, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $419,375 |
| NIH project number | 1R21NS136077-01 |
| Project ID | NIH-10845955 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who suffer from chronic migraines.
✕Less likely to help
Patients who do not experience migraines or have other unrelated neurological conditions may not benefit from this research.
What this research studies
This research focuses on understanding how the GPR37L1 receptor is involved in chronic migraine conditions. By examining genetic variants and their effects on receptor signaling, the study aims to uncover the biological mechanisms that contribute to migraine symptoms. Researchers will use animal models to explore how the absence of this receptor affects brain activity and behavior related to migraines. The findings could lead to new insights into migraine treatment and prevention.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic targets for managing chronic migraines.
How similar studies have gone: Previous research has shown promising results in understanding receptor roles in migraine, suggesting potential for success in this novel investigation.
Where this research is happening
-
Florida Atlantic University
Boca Raton, United States Active
Researchers
- Principal investigator: Cippitelli, Andrea — Florida Atlantic University
- Study coordinator: Cippitelli, Andrea
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.