Suppressive Functions of Regulatory T Cells in Migraine

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study explores the role of regulatory T cells in chronic migraine by analyzing immune cells and related markers. Participants provide blood samples, complete questionnaires, and have a follow-up phone call to monitor data collection. The goal is to understand how immune regulation may influence migraine chronification and inflammation. The study is conducted at CHU Clermont-Ferrand with female adults aged 18–50 who have at least 8 migraine days per month. No drug therapy is described as the primary intervention; the focus is on immune-related assessments.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Females
* 18 to 50 years old
* For chronic migrain : At least 8 monthly migraine days

Exclusion Criteria:

* BMI \< or = 17kg/m² or \> or = 30kg/m²
* Diagnosis or suspicion of type 2 diabetes, auto-immune or inflammatory diseases, immunodeficiency diseases
* Diagnosis of headache of non-migraine origin, except for tension type headache (i.e.: cluster headache, post-traumatic headache, cerebral tumour…)
* For controls participants : tension type headache with 4 or more monthly headache days
* Pregnancy, delivery, miscarriage, breastfeeding, participation in a medically assisted human reproduction program (ovary stimulation/hormone therapy) \< 3 months before blood sampling
* Menopause, hysterectomy, or bilateral oophorectomy
* Modification of prophylactic anti-migraine therapy (start, change of molecule, interruption) \< 1 month before blood sampling (for migraine participants)
* Hormone therapy (beside contraception and treatment of endometriosis)
* Transplantation (solid organ or bone marrow)
* Cancer (active or remitting) \< 1 year before blood sampling (solid organ or blood)
* Haematologic disease (benign or malignant) of the lymphoid lineage
* Guardianship, curatorship, safeguard of justice or deprivation of liberty
* For controls : history of migraine

Where it's running

• CHU Clermont-Ferrand
  Clermont-Ferrand, France Recruiting

Study contacts

• Principal investigator: Xavier MOISSET — University Hospital, Clermont-Ferrand
• Study coordinator: Lise Laclautre
• Email: promo_interne_drci@chu-clermontferrand.fr
• Phone: 334.73.754.963

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.