Understanding how genetic changes affect chronic liver disease
Official title: Elucidating chronic liver disease pathways using somatic genetics
Funded at Ut Southwestern Medical Center · NIH-10937001 · Data updated 2026-11-12
This study is looking at how changes in your genes might affect chronic liver disease and its progression to cirrhosis, with the goal of finding new ways to help manage liver health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | September 15, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $754,400 |
| NIH project number | 1DP1DK139976-01 |
| Project ID | NIH-10937001 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with chronic liver disease or those at risk of developing liver-related complications.
✕Less likely to help
Patients with acute liver conditions or those without any liver disease may not benefit from this research.
What this research studies
This research investigates the complex genetic mechanisms that contribute to chronic liver disease and its progression to cirrhosis. By analyzing somatic mutations that accumulate in liver tissues over time, the study aims to identify genetic alterations that may influence liver health and disease outcomes. The researchers will employ advanced genetic screening techniques to uncover mutations that could either harm or help liver function. This approach could lead to new therapeutic strategies for managing liver diseases.
Why it matters
Potential benefit: If successful, this research could lead to the development of therapies that slow the progression of chronic liver disease and improve patient outcomes.
How similar studies have gone: Other research has shown promise in understanding genetic factors in chronic diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Zhu, Hao — Ut Southwestern Medical Center
- Study coordinator: Zhu, Hao
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.