NIH-funded research R01 grant

Fat and iron–corrected MRI to evaluate chronic liver disease

Official title: Fat and Iron-Corrected Quantitative MRI T1 Mapping for Evaluation of Chronic Liver Disease

Funded at New York University School of Medicine · NIH-11406093 · Data updated 2026-11-12

A new MRI method aims to measure fat, iron, and tissue changes in adults with chronic liver disease to help track MASLD/MASH progression.

More Chronic Liver Disease research and trials

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionNew York University School of Medicine
NIH-funded
Lab location1 site (New York, United States)
Project startSeptember 15, 2025
Project endJuly 31, 2030
Funding year2026
Award (this year)$847,497
NIH project number5R01DK143170-02
Project IDNIH-11406093 on NIH RePORTER

Who could benefit from this research

Could help

Adults with MASLD/MASH or related chronic liver disease who are candidates for non-invasive liver assessment.

Less likely to help

Patients with liver conditions not related to MASLD/MASH or whose disease does not affect MRI measurements may see no benefit.

What this research studies

This project tests a specialized MRI technique that corrects for fat and iron in liver T1 mapping to better measure liver health in adults with MASLD/MASH. It seeks non-invasive markers that capture fat, inflammation, and fibrosis together, potentially reducing the need for liver biopsy. The study will be conducted at New York University School of Medicine under the leadership of Dr. Li Feng and will analyze imaging data from adult participants to correlate MRI findings with liver pathology. If successful, the method could improve how clinicians monitor disease activity and treatment response over time.

Why it matters

Potential benefit: If successful, this MRI approach could provide a safer, non-invasive way to track MASLD/MASH progression and response to therapy.

How similar studies have gone: Previous work shows MRI can assess liver fat and fibrosis non-invasively, but this study aims to refine and combine markers for better accuracy.

Where this research is happening

  • New York University School of Medicine
    New York, United States
    Active

Researchers

  • Principal investigator: Feng, Li — New York University School of Medicine
  • Study coordinator: Feng, Li

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.