Condition

MASH clinical trials and research

• 9Clinical trials
• 14Countries

Newest MASH clinical trials

All recruiting trials (9)

• Resmetirom in children and teens with MASH

  This study tests how safe resmetirom is and how it acts in the body of kids aged 6 to 17 who have MASH with liver fibrosis.

  Recruiting Phase 2 Madrigal Pharmaceuticals, Inc. · Indianapolis, Indiana · NCT07763015

• ALN-CIDEB for adults with fibrotic MASH (phase 2)

  This phase 2 study tests ALN-CIDEB versus placebo to see if it can reduce liver fat, injury, and scarring in adults with fibrotic MASH.

  Recruiting at 24 sites Phase 2 Regeneron Pharmaceuticals · Tucson, Arizona and 23 other locations · NCT07631637

• OPK-88006 in Healthy Adults and People with Presumed MASH

  This study tests OPK-88006 to see if it is safe and how it behaves in the body, first in healthy adults and then in people with presumed MASH.

  Recruiting Phase 1/2 OPKO Health, Inc. · Miami, Florida · NCT07512427

• Validating lab assays, IV catheter techniques, and devices for endocrine, cardiometabolic, and musculoskeletal conditions

  This project will test whether laboratory assays, IV catheter methods, and equipment give consistent, reliable results in adults with or without obesity-related, metabolic, or musculoskeletal conditions.

  Recruiting University of Missouri-Columbia · Columbia, Missouri · NCT07083557

• Prospective NAFLD/NASH patient cohort and biobank

  This project will collect medical data and blood/tissue samples from adults with NAFLD/NASH to create a long-term resource to help researchers understand disease course and causes.

  Recruiting Fondazione Epatocentro Ticino · Lugano, Canton Ticino · NCT07051863

• Endoscopic ultrasound shear wave elastography for measuring liver fibrosis

  This study will test whether endoscopic ultrasound shear wave elastography and attenuation imaging can estimate liver fibrosis compared with biopsy and FibroScan in adults with suspected MASLD or MASH.

  Recruiting at 3 sites Olympus Corporation of the Americas · Newport Beach, California and 2 other locations · NCT06592820

• Digoxin for NASH with stage 2–3 fibrosis

  This trial will see if taking once-daily digoxin helps clear NASH and reduce liver scarring in adults with biopsy-confirmed NASH and stage 2–3 fibrosis.

  Recruiting at 2 sites Phase 2 Yale University · New Haven, Connecticut and 1 other locations · NCT06588699

• Endoscopic sleeve gastroplasty for people with obesity and MASH

  This study will test whether endoscopic sleeve gastroplasty plus lifestyle changes helps adults with obesity and MASH lose weight and improve liver health compared with lifestyle changes alone.

  Recruiting at 2 sites Brigham and Women's Hospital · Boston, Massachusetts and 1 other locations · NCT06138821

• Screening patients at risk for liver disease in Europe

  This study is trying to find out if screening high-risk patients in Europe for liver disease using simple tests can help doctors identify and better understand conditions like metabolic dysfunction-associated steatotic liver disease.

  Recruiting at 6 sites Julius Clinical · Brussels, Vlaams-brabant and 12 other locations · NCT05651724

Related topics

Quick answers

How many MASH clinical trials are recruiting right now?

9, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 14 countries. The most sites are in United States (7 trials), Belgium (1 trial), Czechia (1 trial), France (1 trial), Germany (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 3, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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