Condition

Brain Tumors clinical trials and research

• 11Clinical trials
• 105NIH research projects
• 7Countries

Newest Brain Tumors clinical trials

All recruiting trials (11)

• Smart Holistic Health Care Platform for families of children with cancer

  Aims to see if two smart platforms for parents and children with leukemia or brain tumors in Taiwan can improve quality of life and overall well-being during treatment.

  Recruiting National Defense Medical Center, Taiwan · Taipei · NCT07805096

• Spectral Precise Image study for brain tumors

  Researchers will test the image quality and diagnostic confidence of Spectral Precise Image reconstructions from spectral CT scans in adults with brain tumors.

  Recruiting Philips Clinical & Medical Affairs Global · Wuhan, Hubei · NCT07620470

• rTMS to improve movement after brain tumor surgery

  This pilot will try whether short courses of daily TMS can help adults with new or ongoing movement weakness after brain tumor surgery recover strength and function.

  Recruiting Columbia University · New York, New York · NCT07530536

• Early post-operative brain PET-MRI in glioblastoma surgery

  This study tests whether doing PET-MRI soon after glioblastoma surgery is safe and feasible and whether imaging with 18F-DOPA can better detect residual tumor than standard MRI.

  Recruiting Beta Emitting Accurate Monitored Systems · Créteil · NCT07274397

• Vision-language AI to diagnose brain diseases from imaging and clinical data

  This project will test a new AI that reads scans, pathology, genomics, and clinical records to help diagnose a wide range of brain diseases for patients with tumors, vascular problems, or neurodegeneration.

  Recruiting Xiangya Hospital of Central South University · Changsha, Hunan · NCT07126821

• Improving care pathways for patients with rare brain tumors using AI

  This study is testing whether using AI to improve treatment plans can help people with rare brain tumors have better care and quality of life through a home rehabilitation program.

  Recruiting Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta · Milan, PA and 1 other locations · NCT06878469

• Comparing IV methadone versus IV remifentanil for pain and recovery after craniotomy

  This trial will test whether a single dose of IV methadone given during surgery provides better pain control and recovery than IV remifentanil for adults having supratentorial craniotomy.

  Recruiting Early Phase 1 University of Virginia · Charlottesville, Virginia · NCT06810336

• Identifying biomarkers to predict cognitive decline after radiation therapy for brain tumors

  This study is trying to find specific markers in blood and spinal fluid from young patients with brain tumors to see if they can predict problems with thinking and memory after radiation treatment.

  Recruiting Tata Memorial Centre · Mumbai, Maharashtra · NCT06779487

• Comparing short and long-term use of levetiracetam for seizures in brain tumor patients

  This study tests whether taking levetiracetam for a shorter time can help brain tumor patients with seizures just as well as the standard longer treatment.

  Recruiting Phase 3 Tata Memorial Centre · Udupi, Karnataka and 1 other locations · NCT06442748

• Comparing proton and photon radiotherapy for brain tumors

  This study tests whether proton therapy causes less long-term side effects than photon therapy in patients with different types of brain tumors.

  Recruiting at 2 sites Technische Universität Dresden · Dresden and 1 other locations · NCT02824731

• Collecting brain tumor tissue samples for future research

  This study is collecting leftover brain tumor samples and related information to help researchers find better treatments and cures for brain tumors in the future.

  Recruiting University of Florida · Gainesville, Florida · NCT00811148

NIH-funded research (newest 40 of 105)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• ONC206 for children with brain tumors: a first-in-children trial

  A first-in-children trial will test the safety and early signs of effectiveness of ONC206, taken by mouth, in kids with malignant brain tumors like diffuse midline gliomas.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11535240

• ONC206 for children with malignant brain tumors

  A first-in-children trial tests the safety and early effectiveness of a pill that can cross the brain barrier to treat pediatric brain tumors.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11535239

• ONC206 for children with dangerous brain tumors

  A first-in-children study tests the safety and early effectiveness of an oral drug, ONC206, for kids with high-risk brain tumors that have spread or recurred.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11535238

• Oral bacteria and brain metastasis: how the mouth may influence brain tumors

  A study exploring how oral microbes may affect brain metastases and patient outcomes, with potential to guide new microbiome-based approaches.

  NIH research H. Lee Moffitt Cancer Ctr & Res Inst · Tampa, United States · NIH-11527242

• Bioengineered brain barrier chip to improve drug screening for brain tumors

  A small, patient-friendly brain barrier chip is being developed to test drugs for glioblastoma more accurately before they reach clinical trials.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11453253

• Understanding how epigenetic changes drive pediatric brain tumor recurrence and how reversing them could help

  A pediatric brain cancer research project is exploring how an epigenetic change (H3K27M) and tumor environment contribute to tumor coming back, using a reversible mouse model to study potential ways to prevent recurrence.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11453252

• SleepCARE: a patient-friendly way to help caregivers of brain tumor patients sleep better

  A small grant is testing a telehealth sleep program designed to help caregivers of people with primary malignant brain tumors sleep better and feel less stressed.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11452272

• Targeting MMP14 to overcome therapeutic resistance in brain tumors

  A new drug approach aims to make brain tumor treatments work better by hitting a specific enzyme (MMP14) that helps tumors resist therapy.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11450617

• Potential non-muscle myosin II inhibitor for pediatric brain tumors

  A first-in-class drug approach is being explored to treat a deadly pediatric brain tumor by targeting a motor protein inside cancer cells.

  NIH research University of Florida · Gainesville, United States · NIH-11441649

• One-shot MRI to map brain tumors in a single scan

  A new MRI approach uses one contrast agent to map shape, blood flow, and metabolism of brain tumors in a single session to guide care.

  NIH research Arizona State University-Tempe Campus · Scottsdale, United States · NIH-11418946

• Hyperpolarized carbon-13 MRI to guide brain tumor care

  A new approach uses safe, rapidly acquired metabolic MRI scans to help manage brain tumors like glioblastoma and meningioma.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11413790

• ONC206 for pediatric brain tumors: a first-in-children trial

  A first-in-children trial will test the safety and early effectiveness of ONC206, a pill that can reach brain tumors, in kids with diffuse midline gliomas and other recurrent brain cancers.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11413761

• Tumor-Associated Macrophages and Edema in Brain Tumors

  A study in glioblastoma patients and models looks at how brain swelling (edema) happens and whether targeting specific immune cells can reduce edema without hurting cancer treatment.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11412708

• ONC206 treatment for children with diffuse midline glioma and other recurrent malignant brain tumors

  An oral drug called ONC206 that can reach the brain is being given to children with diffuse midline gliomas and other recurrent malignant brain tumors to check safety and look for early signs of benefit.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11410957

• ONC206 for children with diffuse midline gliomas and other recurrent malignant brain tumors

  This trial tests a new oral drug called ONC206 that can reach the brain in children with diffuse midline gliomas and other recurrent malignant brain tumors to check safety and early signs it can fight tumors.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11410956

• ONC206 — an oral drug for children with diffuse midline glioma and recurrent malignant brain tumors

  This work will see if the oral drug ONC206 is safe and shows early signs of benefit for children with diffuse midline glioma and other recurrent malignant brain tumors.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11410955

• FearLess: a brain tumor patient and caregiver mindfulness program

  A new, patient-friendly mental health program called FearLess aims to help people with primary malignant brain tumors and their caregivers cope with fear of cancer recurrence.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-11405501

• Personalized brain tumor therapies: mapping mutations to immune targets

  A researcher-led effort at a major university aims to map brain tumor mutations to immunogenic targets so patients with brain tumors could receive personalized immune-based therapies.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11398280

• Brain tumor research aiming to tailor therapy for glioblastoma patients

  Aimed at understanding glioblastoma at the cellular level to find patient groups and tailor personalized therapies.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11395427

• Targeting brain tumors with cell-penetrating anti-nucleic acid antibodies

  A study exploring a new way to treat glioblastoma by using special antibodies that can enter brain tumor cells and deliver drugs or rewire the tumor environment.

  NIH research Yale University · New Haven, United States · NIH-11391685

• Image-based tools to guide treatment for kids with brain tumors

  A pediatric brain tumor project is developing MRI-based computer tools to help doctors tailor therapy and reduce side effects for children with brain cancer.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11385379

• Targeting immune cells to boost brain tumor treatments

  A clinician-scientist at Case Western Reserve University will study how immune-supporting cells in brain tumors become suppressive and hinder immunotherapy, with training to lead independent research in this area.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11384888

• Antibody-drug conjugates to help brain tumor patients

  A Mayo Clinic team is testing targeted antibody-drug conjugates to treat glioblastoma, aiming to attack cancer cells in the brain while limiting harm to normal tissue.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11382264

• Targeting T Cells to Boost Anti-Tumor Immunity in Pediatric Brain Tumors

  A physician-scientist team at UC San Diego is testing whether enhancing tumor-fighting T cells can help kids with brain tumors.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11379532

• Optical Genome Mapping to Improve Diagnosis of Pediatric Brain Tumors

  A new test using Optical Genome Mapping could help diagnose brain tumors in children faster and more accurately, guiding better treatment choices.

  NIH research Lurie Children's Hospital of Chicago · Chicago, United States · NIH-11372183

• Targeting the causes of childhood medulloblastoma

  Researchers are using animal models and children's tumor samples to find what drives deadly medulloblastoma and try ways to block it.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11370263

• Long‑term radiation planning for kids’ brain tumors using AI for safer, more precise treatment

  A pediatric brain tumor grant tests AI‑assisted radiation planning to spare healthy brain tissue and protect cognitive development.

  NIH research Voxel Healthcare, LLC · Pasadena, UNITED STATES · NIH-11364918

• Immune cells and brain swelling in glioblastoma

  Researchers are testing whether blocking inflammation from tumor-associated immune cells can reduce dangerous brain swelling in people with glioblastoma while keeping radiation therapy effective.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11351684

• Oncolytic HSV therapy to boost brain tumor fighting power

  A treatment using engineered herpes simplex virus designed to attack glioblastoma while helping the immune system fight the cancer in the brain.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11348941

• Encapsulated stem-cell delivery of a cancer-killing virus for brain tumors

  This project uses ready-made stem cells encased in a gel to deliver a tumor-killing herpesvirus to target leftover glioblastoma cells after surgery.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11330479

• Blocking a sugar-making pathway in childhood midline brain tumors

  This work tests whether shutting down the hexosamine (sugar-making) pathway, alone or with drugs that block glycolysis, can better kill diffuse midline gliomas that affect children.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11330380

• Brain cancer immunology: CCL3's role in boosting immune attack on tumors

  A Duke University team is studying how the CCL3 chemical signal helps the immune system fight glioblastoma by improving dendritic cell work and T cell movement.

  NIH research Duke University · Durham, United States · NIH-11321164

• Liquid biopsy for brain tumors: using DNA methylation in blood to guide brain cancer care

  A study aims to test if measuring DNA methylation patterns in blood can reliably help diagnose brain tumors and monitor treatment without invasive brain surgery.

  NIH research University Health Network · Toronto, Canada · NIH-11319801

• Blood-based test to subtype brain tumors (gliomas) using a multi-mutation blood assay

  A blood test called GLIscan aims to help doctors quickly identify the type of glioma in a patient using a few key tumor mutations from a blood sample.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11311379

• Imaging how brain tumors hijack existing blood vessels

  Using detailed imaging and models to find brain-scan signs that gliomas (including glioblastoma) grow by taking over existing blood vessels, to help people with brain tumors.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11306695

• Blood immune cells and their role in glioblastoma

  Learning how two types of blood immune cells, monocytes and neutrophils, enter and change glioblastoma tumors to help people with this aggressive brain cancer.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11306611

• Better treatments for children with brain tumors using molecular testing and targeted medicines

  This work uses tumor genetic testing to match children with brain tumors to targeted medicines aimed at helping them live longer with fewer long-term side effects.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11302671

• Annotating brain tumor and birth defect genetic drivers

  Researchers are studying how genetic differences that cause birth defects may also drive embryonal brain tumors, with the goal of clearer DNA clues for kids.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11295247

• Imaging tumor acidity and sodium to tell invading from growing brain tumor cells

  This project uses advanced MRI techniques that read water and sodium signals to tell which parts of a brain tumor are invading nearby tissue versus actively growing.

  NIH research Yale University · New Haven, United States · NIH-11294295

• Implantable scaffolds to make CAR‑T therapy stronger and cheaper for brain tumors

  This project aims to use a biocompatible implant placed at the tumor site to help CAR‑T immune cells reach and kill glioblastoma cells while reducing the need for repeated, costly infusions.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11294220

Related topics

Quick answers

How many Brain Tumors clinical trials are recruiting right now?

11, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 7 countries. The most sites are in United States (3 trials), China (2 trials), India (2 trials), Italy (1 trial), France (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 1, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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