Brain tumor research aiming to tailor therapy for glioblastoma patients
Official title: Oncogenic mechanisms, molecular stratification and therapeutic targets of brain tumors
Funded at University of Miami School of Medicine · NIH-11395427 · Data updated 2026-11-12
Aimed at understanding glioblastoma at the cellular level to find patient groups and tailor personalized therapies.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project start | September 24, 2021 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $917,902 |
| NIH project number | 5R35CA253183-07 |
| Project ID | NIH-11395427 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with glioblastoma (brain tumors) whose tumors can be classified into homogeneous subgroups based on molecular profiles.
✕Less likely to help
Patients whose tumors do not fit the identified subgroup patterns or who cannot benefit from the targeted approaches developed.
What this research studies
Researchers will combine computational analysis with advanced lab models to identify subgroups of glioblastoma patients who share key pathway activations. They will study cancer heterogeneity at the single-cell level to refine tumor classification. The project will develop a new computational-experimental framework and use high-throughput, single-cell transcriptomic and proteomic analyses of glioma tissues to uncover driver modules and potential therapeutic targets. Findings could lead to more precise treatments for patients with this aggressive brain cancer.
Why it matters
Potential benefit: If successful, patients with glioblastoma could receive more personalized and effective therapies.
How similar studies have gone: Previous work has identified targeted opportunities in glioblastoma and is being explored in clinical studies, indicating potential but still early-stage successes.
Where this research is happening
-
University of Miami School of Medicine
Coral Gables, United States Active
Researchers
- Principal investigator: Iavarone, Antonio — University of Miami School of Medicine
- Study coordinator: Iavarone, Antonio
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.