Targeting immune cells to boost brain tumor treatments
Official title: Targeting myeloid cells to increase efficacy of immunotherapy against brain tumors.
Funded at Case Western Reserve University · NIH-11384888 · Data updated 2026-11-12
A clinician-scientist at Case Western Reserve University will study how immune-supporting cells in brain tumors become suppressive and hinder immunotherapy, with training to lead independent research in this area.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | July 19, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $211,464 |
| NIH project number | 5K08CA276819-04 |
| Project ID | NIH-11384888 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with brain tumors who could benefit from improved immunotherapy and from future trials related to brain tumor immunology.
✕Less likely to help
Patients with tumors not driven by immune suppression may see limited direct benefit.
What this research studies
This early-career grant supports a physician-scientist as they learn advanced immune biology and connect lab findings to potential brain cancer therapies. The project focuses on the immune cells inside brain tumors that dampen treatment effects and explores how to overcome this suppression. The fellow will gain leadership, grant-writing, and scientific communication skills while conducting hands-on experiments and collaborating with world-class mentors. The goal is to prepare the researcher to run an independent lab that discovers new ways to improve brain cancer immunotherapy.
Why it matters
Potential benefit: If successful, this work could reveal targets to make brain cancer immunotherapy work better for patients.
How similar studies have gone: Previous studies have demonstrated the critical role of tumor-associated myeloid cells in suppressing immune responses, supporting the rationale for this approach.
Where this research is happening
-
Case Western Reserve University
Cleveland, United States Active
Researchers
- Principal investigator: Miller, Tyler Eugene — Case Western Reserve University
- Study coordinator: Miller, Tyler Eugene
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.