Condition

Benign Prostatic Hyperplasia clinical trials and research

• 42Clinical trials
• 3NIH research projects
• 31Countries

Newest Benign Prostatic Hyperplasia clinical trials

All recruiting trials (42)

• Sonablate HIFU Registry for Prostate Cancer and BPH

  This registry collects real-world data from men treated with Sonablate HIFU to see how well it works and how it affects urinary and sexual function over the long term.

  Recruiting Sonablate · Indianapolis, Indiana · NCT07757490

• Tamsulosin alone vs. tamsulosin with tadalafil for troublesome urinary symptoms from enlarged prostate

  This study tests whether adding tadalafil to tamsulosin helps men with BPH see better urinary symptoms and quality of life, using two tadalafil doses over 12 weeks.

  Recruiting Ain Shams University · Cairo, Cairo Governorate · NCT07722884

• MRI-DTI look at the urethral sphincter ring and prostate base shape

  This imaging study tests how the male urethral internal sphincter ring appears on MRI-DTI and how it relates to prostate base morphology in men undergoing clinically indicated MRI.

  Recruiting Jiangsu Taizhou People's Hospital · Taizhou, Jiangsu · NCT07694752

• Tamsulosin With or Without Tadalafil for a Trial Without Catheter After Acute Urinary Retention

  This study tests whether adding tadalafil to tamsulosin helps men with a first episode of acute urinary retention due to enlarged prostate pass urine without needing a catheter.

  Recruiting Phase 4 Beni-Suef University · Banī Suwayf, Beni Suweif Governorate · NCT07654413

• Tamsulosin dose change or switch to silodosin before catheter removal in men with BPH-related acute urinary retention

  This trial tests whether continuing tamsulosin, increasing its dose, or switching to silodosin helps men with BPH-related acute urinary retention go without a catheter after seven days.

  Recruiting Phase 4 Beni-Suef University · Banī Suwayf, Beni Suweif Governorate · NCT07650968

• Water Vapor Therapy vs Ejaculation-Sparing Enucleation for Benign Prostatic Hyperplasia

  This study tests whether Water Vapor Thermal Therapy (Rezum) or an ejaculation-sparing enucleation procedure better helps sexually active men with bothersome BPH symptoms.

  Recruiting Beni-Suef University · Banī Suwayf, Beni Suweif Governorate · NCT07648888

• Water Vapor Therapy versus Ejaculation-Preserving HoLEP for Benign Prostatic Hyperplasia

  This study compares Rezum water vapor therapy to ejaculation-preserving HoLEP in sexually active men with moderate-to-severe symptoms from BPH to see which preserves ejaculation better while easing urinary symptoms.

  Recruiting Beni-Suef University · Banī Suwayf, Beni Suweif Governorate · NCT07648875

• Spinal vs. General Anesthesia for Open Simple Prostatectomy

  This trial tests whether spinal anesthesia reduces postoperative bleeding compared with general anesthesia in men undergoing open simple prostatectomy for BPH.

  Recruiting at 2 sites Hitit University · Çorum and 1 other locations · NCT07643415

• Magneto 150 vs MOSES 2.0 for HoLEP in Benign Prostatic Hyperplasia

  This trial tests whether the Magneto 150 holmium laser can shorten intraoperative bleeding time compared with MOSES 2.0 during HoLEP for enlarged prostate.

  Recruiting Northwestern University · Chicago, Illinois · NCT07632742

• Ejaculation-Preserving Bipolar Prostate Enucleation for BPH

  This randomized trial tests whether a modified ejaculation-preserving bipolar TUEP can maintain ejaculation while still relieving urinary symptoms in sexually active men with BPH who didn’t improve with meds.

  Recruiting Beni-Suef University · Banī Suwayf, Beni Suweif Governorate · NCT07629479

• Bioblation: Combined biopsy and laser treatment for prostate symptoms and suspected cancer

  A single-session procedure (Bioblation) combines a trans-perineal prostate biopsy with laser ablation to relieve severe LUTS and treat likely low- to favorable intermediate-risk prostate cancer.

  Recruiting Benha University · Banhā, Qalyubia Governorate · NCT07526675

• Tranexamic acid to reduce bleeding during TURP

  This trial tests whether giving tranexamic acid before TURP helps reduce blood loss for men 50 and older with BPH.

  Recruiting Phase 4 Military Teaching Hospital Mohammed V · Rabat · NCT07460518

• Safety and how the body handles AD-116 and AD-1161 in healthy adult men

  This will test how safe AD-116 and AD-1161 are and how the body processes them in healthy adult men after a meal.

  Recruiting Phase 1 Addpharma Inc. · Seoul · NCT07444385

• Extended ambulatory bladder monitoring with the Glean Urodynamics System

  This will test whether the Glean Urodynamics System can safely monitor bladder function in adults who need urodynamic testing, both during a clinic visit and for up to 24 hours at home.

  Recruiting at 8 sites Bright Uro · New Orleans, Louisiana and 8 other locations · NCT07425015

• Lingze tablets plus tamsulosin to improve sleep and nighttime urination after prostate enucleation

  We will test whether adding the herbal Lingze tablets to tamsulosin helps men 50 and older who still wake two or more times per night to urinate after HoLEP.

  Recruiting Phase 4 The Fourth Affiliated Hospital of Zhejiang University School of Medicine · Yiwu, Zhejiang · NCT07357324

• Smart wearable for monitoring bladder function in men with BPH

  A non-invasive wearable device is tested to see if it can measure bladder function as accurately as the standard uroflowmetry test in men with BPH.

  Recruiting Peking University Third Hospital · Beijing, HaiDian and 1 other locations · NCT07357012

• Pelvic floor exercises to improve urinary symptoms after enlarged prostate surgery

  This trial will try pelvic floor muscle exercises to see if they reduce urinary symptoms and improve quality of life in men after surgery for benign prostatic hyperplasia (enlarged prostate).

  Recruiting at 2 sites Taipei Medical University WanFang Hospital · Taipei and 1 other locations · NCT07293442

• Edison System histotripsy treatment for enlarged prostate (BPH)

  This will test whether the HistoSonics Edison System's histotripsy procedure is safe for men 50 and older with symptomatic enlarged prostate (BPH).

  Recruiting HistoSonics, Inc. · Shatin · NCT07214675

• Evaluating a new therapy for benign prostatic hyperplasia

  This study tests a new treatment called steep pulse therapy for men with benign prostatic hyperplasia to see if it works better than the usual medication.

  Recruiting at 10 sites First Affiliated Hospital of Zhejiang University · Hefei, Anhui and 9 other locations · NCT06867315

• Patient experiences after surgery for benign prostatic hyperplasia

  This study is trying to understand how men over 50 recover after surgery for an enlarged prostate by tracking their pain, urinary symptoms, and medication use for three months.

  Recruiting Sahlgrenska University Hospital · Alingsås and 2 other locations · NCT06852859

• Comparing two treatments for prostate issues

  This study is testing whether a new water vapor treatment for prostate issues works just as well as a popular lift procedure for men over 50 with BPH symptoms.

  Recruiting Chinese University of Hong Kong · Hong Kong · NCT06820606

• HoLEP versus bipolar enucleation for men with large prostates

  This will test whether bipolar enucleation works as well as Holmium Laser Enucleation (HoLEP) for men over 50 with large prostates who need surgery for BPH.

  Recruiting Assiut University · Asyut · NCT06759194

• Treatment of enlarged prostate using water vapor therapy

  This study is testing if a new water vapor treatment can help men with an enlarged prostate feel better by reducing their symptoms.

  Recruiting at 10 sites Medtecx Co Ltd. · Hefei, Anhui and 9 other locations · NCT06725212

• Beacon robotic platform to assist Holmium Laser Enucleation of the Prostate (HoLEP)

  This tests whether the Beacon robotic platform helps surgeons perform HoLEP for men with benign prostatic enlargement who have urinary symptoms or retention.

  Recruiting at 3 sites Andromeda Surgical · Santiago, Santiago Metropolitan and 2 other locations · NCT06668142

• Local anesthesia for water vapor therapy in treating benign prostatic hyperplasia

  This study is testing if using a special catheter for local anesthesia during water vapor therapy can help men with benign prostatic hyperplasia feel less pain and improve their quality of life compared to general anesthesia.

  Recruiting Assistance Publique Hopitaux De Marseille · Marseille · NCT06657872

• Evaluating the effectiveness of Rezum water vapor therapy for prostate enlargement

  This study is testing if Rezum water vapor therapy can safely help men over 50 with prostate enlargement feel better and improve their symptoms.

  Recruiting Saint Vincent's Hospital, Korea · Suwon, Gyeonggi-do · NCT06656689

• High-intensity Focused Ultrasound treatment for enlarged prostate

  This study is testing a non-invasive ultrasound treatment for men aged 50 to 85 with an enlarged prostate to see if it can improve their urinary symptoms when other treatments haven't worked.

  Recruiting at 2 sites Edap Tms S.a. · Besançon and 8 other locations · NCT06601179

• Registry for Transperineal Laser Ablation of Prostate for Urinary Symptoms

  This study is testing how well Transperineal Laser Ablation of the prostate helps men with urinary problems caused by an enlarged prostate and looks at how different patients respond to the treatment.

  Recruiting University of Florence · Florence · NCT06564415

• Observational study on BPH treatment in Greek men

  This study is trying to see if a combination of two medications can help Greek men with moderate to severe BPH symptoms feel better when other treatments haven't worked well enough.

  Recruiting at 5 sites Elpen Pharmaceutical Co. Inc. · Athens, Greece and 5 other locations · NCT06528613

• Treatment for male overactive bladder using sacral neuromodulation

  This study is testing a new device to see if it can help men with overactive bladder feel better after prostate surgery or radiation therapy.

  Recruiting at 21 sites Axonics, Inc. · Birmingham, Alabama and 22 other locations · NCT06511141

• Innovative treatment for benign prostatic hyperplasia and varicocele

  This study is testing a new, less invasive surgery for men with benign prostatic hyperplasia and varicoceles to see if it can improve their symptoms and reduce complications compared to traditional methods.

  Recruiting Vivifi Medical · Panama City, Provincia de Panamá · NCT06424912

• Evaluating the Optilume BPH Catheter System for treating enlarged prostate

  This study is testing the Optilume BPH Catheter System to see if it can help men with an enlarged prostate feel better and improve their urinary symptoms over a year.

  Recruiting at 7 sites Urotronic Inc. · Little Rock, Arkansas and 6 other locations · NCT06312722

• Observing the quality of life in patients with benign prostatic hyperplasia

  This study looks at how different treatments for benign prostatic hyperplasia affect the daily lives and well-being of patients.

  Recruiting IRCCS San Raffaele · Milan, Lombardy · NCT06182189

• Improving care for men with benign prostatic hyperplasia using patient feedback

  This study is testing if using feedback from men with benign prostatic hyperplasia can help doctors provide better care and improve their quality of life by focusing on a wider range of symptoms.

  Recruiting Northwestern University · Glenview, Illinois · NCT05898932

• Comparing two surgical methods for treating prostate enlargement while preserving ejaculation

  This study is testing two different surgical methods for treating prostate enlargement in men to see which one helps improve urinary symptoms while also preserving the ability to ejaculate.

  Recruiting at 13 sites University Hospital, Bordeaux · Aix-en-Provence and 16 other locations · NCT05574244

• Global registry for benign prostatic hyperplasia treatments

  This study is collecting information from men with benign prostatic hyperplasia to see how different treatments work and to help improve future care.

  Recruiting at 22 sites Société Internationale d'Urologie · Los Angeles, California and 29 other locations · NCT05543200

• Assessing treatment outcomes for benign prostate hyperplasia in Hong Kong

  This study is trying to see how well different surgical treatments for benign prostate hyperplasia work for men in Hong Kong who have not found relief from their urinary symptoms with medication.

  Recruiting at 3 sites Chinese University of Hong Kong · Hong Kong and 2 other locations · NCT05292235

• Urolift Before SBRT to Try to Lower Urinary Side Effects in Men with BPH and Prostate Cancer

  This study tests whether doing Urolift before SBRT can lessen urinary side effects for men with BPH and prostate cancer needing radiation therapy.

  Recruiting Northwell Health · Syosset, New York · NCT05148156

• Registry for patients undergoing TULSA procedure for prostate conditions

  This study is tracking patients who have had the TULSA procedure for prostate issues to see how safe and effective it is and how it affects their quality of life over time.

  Recruiting at 5 sites Profound Medical Inc. · West Hills, California and 4 other locations · NCT05001477

• Comparing prostate artery embolization to surgery for enlarged prostate treatment

  This study is testing whether a new procedure called prostate artery embolization works as well as traditional surgery for men with an enlarged prostate and bothersome urinary symptoms.

  Recruiting Oslo University Hospital · Oslo · NCT04084938

• Registry for assessing treatments of benign prostatic hyperplasia

  This study is collecting information to see how well different treatments for enlarged prostate symptoms work, comparing new options with traditional ones for men aged 18 and older.

  Recruiting Cantonal Hospital of St. Gallen · Sankt Gallen, Canton of St. Gallen · NCT03521648

• Managing anticoagulation in patients with benign prostatic hyperplasia undergoing laser surgery

  This study is testing whether keeping patients on blood thinners or stopping them before laser surgery for prostate enlargement is safer and leads to fewer complications.

  Recruiting Clinique Pasteur · Toulouse · NCT03297281

NIH-funded research (3)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Enhanced patient-reported tools to guide easy, real-time decisions for benign prostatic hyperplasia

  A clinical project will use patient-reported symptom surveys to help doctors choose the best treatments for men with benign prostatic hyperplasia.

  NIH research University of Chicago · Chicago, United States · NIH-11416370

• Fat-rich TREM2+ immune cells that may drive an enlarged prostate

  This project looks at whether fat-filled immune cells called TREM2+ macrophages cause prostate enlargement and if targeting them could help men with BPH.

  NIH research Endeavor Health Clinical Operations · Evanston, United States · NIH-11339278

• Noninvasive treatment for enlarged prostate tissue

  This study is testing a new, gentle ultrasound treatment called histotripsy to help break down tough tissue in the prostate that causes urinary problems for older men with benign prostatic hyperplasia (BPH), aiming to make treatment easier and quicker without the need for surgery.

  NIH research University of Washington · Seattle, United States · NIH-10652668

Related topics

Quick answers

How many Benign Prostatic Hyperplasia clinical trials are recruiting right now?

42, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 31 countries. The most sites are in United States (9 trials), Egypt (8 trials), China (6 trials), Hong Kong (4 trials), France (4 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 4, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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