Condition

Localized Prostate Cancer clinical trials and research

• 14Clinical trials
• 13NIH research projects
• 9Countries

Newest Localized Prostate Cancer clinical trials

All recruiting trials (14)

• Intraoperative Hyperspectral Imaging to guide prostate cancer removal

  This study tests a hyperspectral imaging device during prostate surgery to see if it can help identify cancer at the edges of the removed tissue in men with localized prostate cancer.

  Recruiting University Hospital, Geneva · Geneva, Canton of Geneva · NCT07826858

• Focal Micro-boost Radiotherapy for Localized Prostate Cancer

  This study tests whether adding a small, targeted boost to MRI-visible prostate lesions during moderately hypofractionated radiotherapy can improve cancer control in men with localized intermediate- to high-risk prostate cancer.

  Recruiting Regina Elena Cancer Institute · Rome, Lazio · NCT07792993

• Sonablate HIFU Registry for Prostate Cancer and BPH

  This registry collects real-world data from men treated with Sonablate HIFU to see how well it works and how it affects urinary and sexual function over the long term.

  Recruiting Sonablate · Indianapolis, Indiana · NCT07757490

• Water IV: See if Aquablation helps localized prostate cancer patients choose active surveillance

  This trial tests whether Aquablation therapy can be as safe and effective as choosing active surveillance for men with localized prostate cancer who are considering surveillance instead of immediate treatment.

  Recruiting at 12 sites PROCEPT BioRobotics · Chandler, Arizona and 27 other locations · NCT07650448

• Whole-gland prostate dose boost versus SBRT alone for PSMA-staged localized and locally advanced prostate cancer

  We will test whether adding a whole-gland radiation boost (with brachytherapy or a stereotactic boost) improves cancer control compared with SBRT alone in men whose prostate cancer is confined to the prostate on PSMA PET.

  Recruiting Phase 2/3 Affidea Nu-med Center of Oncological DIagnostics and Therapy · Zamość, Lublin Voivodeship · NCT07426055

• Oxybutynin ER to help early urinary continence after robotic prostatectomy

  This trial will test whether taking a daily extended-release oxybutynin pill helps men regain urinary control sooner after robot-assisted prostate removal.

  Recruiting National Taiwan University Hospital · Taipei · NCT06966778

• Comparing adaptive SBRT to standard image-guided SBRT for localized prostate cancer

  This study is testing if a new type of targeted radiation therapy for prostate cancer can improve urinary health compared to the standard radiation treatment.

  Recruiting Phase 3 University Health Network, Toronto · Toronto, Ontario · NCT06825091

• Using high-intensity focused ultrasound to treat localized prostate cancer

  This study is testing a new ultrasound treatment for localized prostate cancer to see if it works as well as surgery.

  Recruiting RenJi Hospital · Shanghai, Shanghai Municipality · NCT06362577

• Comparing two types of radiotherapy for localized prostate cancer after surgery

  This study is testing whether a new type of radiotherapy after prostate surgery is safer and more effective than the standard treatment for men with localized prostate cancer.

  Recruiting Changhai Hospital · Shanghai, Shanghai Municipality · NCT06325995

• Radical hypofractionated radiotherapy for localized prostate cancer

  This study is testing a new way of giving radiation therapy to see if it can safely treat localized prostate cancer while causing fewer side effects.

  Recruiting Changhai Hospital · Shanghai, Shanghai Municipality · NCT06325774

• Reducing prostate cancer treatment from 5 to 3 doses of radiotherapy

  This study is testing whether giving fewer doses of radiotherapy for early prostate cancer can still be just as effective and have fewer side effects for patients.

  Recruiting NHS Lothian · Edinburgh · NCT06117059

• Using 18F-DCFPyL Imaging to Evaluate Prostate Cancer Treatment Response

  This study is testing whether a special imaging agent can help doctors see how well treatment is working for men with localized prostate cancer who are receiving radiation therapy.

  Recruiting Phase 2 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT05155046

• Carbon ion therapy with imaging guidance for prostate cancer

  This study is testing if a new type of radiation therapy using carbon ions can effectively treat localized prostate cancer while keeping side effects low.

  Recruiting Phase 2 Shanghai Proton and Heavy Ion Center · Shanghai · NCT05010343

• Atezolizumab-based therapy for men with localized prostate cancer before surgery

  This study is testing a new immunotherapy treatment for men with localized prostate cancer to see if it helps their immune system fight the cancer before they have surgery.

  Recruiting at 2 sites Phase 2 University of California, San Francisco · San Francisco, California and 1 other locations · NCT03821246

NIH-funded research (13)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Deep learning MRI biomarkers to predict prostate cancer outcomes

  A Yale-led project uses advanced MRI images and artificial intelligence to better predict how localized prostate cancer will behave in patients.

  NIH research Yale University · New Haven, United States · NIH-11449993

• Exercise therapy to slow progression in localized prostate cancer on active surveillance

  A study will test whether a structured home-based exercise program helps men with localized prostate cancer who are on active surveillance avoid moving to treatment or worsening, compared with usual care.

  NIH research Beckman Research Institute/city of Hope · Duarte, United States · NIH-11418494

• Biomarkers to identify aggressive prostate cancer early

  A patient-friendly program to find and validate biomarkers in urine and tumor tissue that can flag aggressive prostate cancer early so men can get the right treatment sooner.

  NIH research Old Dominion University · Norfolk, United States · NIH-11415029

• Home walking program for men on active surveillance for low-risk prostate cancer

  This project sees if a year-long home treadmill walking program can change cancer-related markers and help men with low-grade prostate cancer on active surveillance avoid early treatment.

  NIH research Beckman Research Institute/city of Hope · Duarte, United States · NIH-11387134

• Precision pre-surgery therapy for high-risk PTEN-loss prostate cancer

  This grant plans a targeted, pre-surgical treatment for men with high-risk localized prostate cancer who have PTEN loss, using intensified hormone therapy plus an AKT inhibitor before surgery.

  NIH research Portland VA Medical Center · Portland, United States · NIH-11291871

• Better tests to find aggressive early prostate cancer

  This project develops urine and tissue biomarker tests and decision tools to help men with early prostate cancer learn whether their cancer is likely to be aggressive and needs treatment.

  NIH research Old Dominion University · Norfolk, United States · NIH-11191534

• Targeted therapy for aggressive prostate cancer with PTEN loss

  This study is testing a new treatment for men with high-risk localized prostate cancer that has lost a specific gene, aiming to combine hormone therapy with a special drug before surgery to help shrink the cancer and improve outcomes.

  NIH research Portland VA Medical Center · Portland, United States · NIH-11118672

• Understanding genetic communication for localized prostate cancer

  This study is looking at how men with localized prostate cancer and their caregivers talk about new genetic tests that can help with treatment choices, and it wants to see if educational videos can make these conversations easier for everyone, no matter their background.

  NIH research Mayo Clinic Arizona · Scottsdale, United States · NIH-10918068

• Evaluating gene expression tests for localized prostate cancer treatment decisions

  This study is looking at how gene testing can help find the best treatment for men with localized prostate cancer, so they can avoid unnecessary treatments and get the right care based on their individual risk.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-10913497

• Identifying biomarkers for aggressive prostate cancer

  This study is looking for special markers in prostate fluids and tumor tissues to help tell the difference between aggressive and non-aggressive prostate cancer, so that patients can get more personalized treatment based on their specific risk.

  NIH research Old Dominion University · Norfolk, United States · NIH-10911311

• Examining the effects of exercise therapy on prostate cancer progression

  This study is looking at how regular treadmill walking at home might help men with low-grade localized prostate cancer who are being closely monitored, to see if it can change their cancer in a positive way and possibly lessen the need for tougher treatments.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-10911176

• Using AI to predict the progression of high-risk localized prostate cancer

  This study is looking to help veterans with high-risk localized prostate cancer by using advanced technology to better predict how likely they are to stay cancer-free, so doctors can tailor treatments to each patient's needs.

  NIH research VA Greater Los Angeles Healthcare System · Los Angeles, United States · NIH-10907633

• Investigating how centrosome instability contributes to prostate cancer

  This study is looking at how problems with tiny structures in our cells, called centrosomes, might contribute to prostate cancer, with the hope of finding better ways to diagnose and treat the disease for patients like you.

  NIH research University of Arizona · Tucson, United States · NIH-10664978

Related topics

Quick answers

How many Localized Prostate Cancer clinical trials are recruiting right now?

14, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 9 countries. The most sites are in United States (4 trials), China (4 trials), United Kingdom (1 trial), Poland (1 trial), Switzerland (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 3, Phase 2/3: 1, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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