Tranexamic acid to reduce bleeding during TURP

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective, randomized, quadruple-blind, placebo-controlled study conducted at Mohammed V Military Teaching Hospital in Rabat, Morocco. Men aged 50 years or older with benign prostatic hyperplasia undergoing elective TURP under spinal anesthesia are randomly assigned to receive tranexamic acid (10 mg/kg) or placebo before surgery. The study uses two primary haemostatic endpoints: total haemoglobin mass recovered in irrigation irrigation effluent and postoperative hemoglobin at 24 hours, with secondary outcomes including recovery metrics, transfusion need, length of stay, safety, and hospital-level economic impact. An interim analysis will assess feasibility, treatment effect, and safety signals while maintaining blinding. This trial is investigator-initiated and aims to determine if perioperative TXA can improve perioperative blood management in TURP within an enhanced recovery pathway.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Male patients aged 50 years or older
* Diagnosed with benign prostatic hyperplasia (BPH)
* Scheduled for elective transurethral resection of the prostate (TURP) under spinal anesthesia
* American Society of Anesthesiologists (ASA) physical status I-III
* Provided written informed consent

Exclusion Criteria:

* History of thromboembolic disease (deep vein thrombosis, pulmonary embolism, stroke)
* Known hypersensitivity to tranexamic acid
* Severe renal impairment (creatinine clearance \<30 mL/min)
* Coagulation disorders
* Current anticoagulant therapy not appropriately discontinued
* History of seizure disorder
* Refusal to participate

Where it's running

• Mohammed V Military Teaching Hospital
  Rabat, Morocco Recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Sonablate HIFU Registry for Prostate Cancer and BPH

  This registry collects real-world data from men treated with Sonablate HIFU to see how well it works and how it affects urinary and sexual function over the long term.

  Recruiting Sonablate · Indianapolis, Indiana · NCT07757490

• Tamsulosin alone vs. tamsulosin with tadalafil for troublesome urinary symptoms from enlarged prostate

  This study tests whether adding tadalafil to tamsulosin helps men with BPH see better urinary symptoms and quality of life, using two tadalafil doses over 12 weeks.

  Recruiting Ain Shams University · Cairo, Cairo Governorate · NCT07722884

• Appropriateness of Hemostatic Agent Use in Cardiovascular Surgery

  This study tests how well surgeons’ choices about topical hemostatic agents match current guidelines in cardiac and vascular surgery at one Milan hospital.

  Recruiting University of Milan · Milan, MI · NCT07699016

• MRI-DTI look at the urethral sphincter ring and prostate base shape

  This imaging study tests how the male urethral internal sphincter ring appears on MRI-DTI and how it relates to prostate base morphology in men undergoing clinically indicated MRI.

  Recruiting Jiangsu Taizhou People's Hospital · Taizhou, Jiangsu · NCT07694752

• Tamsulosin With or Without Tadalafil for a Trial Without Catheter After Acute Urinary Retention

  This study tests whether adding tadalafil to tamsulosin helps men with a first episode of acute urinary retention due to enlarged prostate pass urine without needing a catheter.

  Recruiting Phase 4 Beni-Suef University · Banī Suwayf, Beni Suweif Governorate · NCT07654413

• Tamsulosin dose change or switch to silodosin before catheter removal in men with BPH-related acute urinary retention

  This trial tests whether continuing tamsulosin, increasing its dose, or switching to silodosin helps men with BPH-related acute urinary retention go without a catheter after seven days.

  Recruiting Phase 4 Beni-Suef University · Banī Suwayf, Beni Suweif Governorate · NCT07650968

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.