Condition

Overactive Bladder clinical trials and research

• 25Clinical trials
• 18NIH research projects
• 8Countries

Newest Overactive Bladder clinical trials

All recruiting trials (25)

• Flyte device to help urinary incontinence after pelvic radiation for endometrial or cervical cancer

  This study tests whether a home-use Flyte device, used during guided pelvic floor exercises, can improve urinary incontinence in women who had pelvic radiation for endometrial or cervical cancer.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07662824

• Self-Start Macrobid for post-Botox lower urinary symptoms

  This study tests whether giving a standing prescription for Macrobid after Botox treatment reduces urgent calls, messages, and visits for urinary symptoms compared with usual triage care.

  Recruiting Early Phase 1 The Cleveland Clinic · Cleveland, Ohio · NCT07648290

• ZIDA Control Sock added to medication for overactive bladder with leakage

  This trial will try using the ZIDA Control Sock once a week at home for 12 weeks to see if adding it to your current medication reduces urgency urinary incontinence.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT07432659

• Vaginal radiofrequency treatment targeting bladder nerves for overactive bladder in women

  This trial will test whether a single vaginal radiofrequency treatment with the MORPHEUSV device can reduce urgency-related urine leaks in adult women with overactive bladder.

  Recruiting at 5 sites InMode MD Ltd. · Palo Alto, California and 8 other locations · NCT07209397

• Tensi+ European registry for overactive bladder

  This registry will collect information on adults with overactive bladder who use the Tensi+ posterior tibial nerve stimulation device to see if it helps symptoms and is safe over one year.

  Recruiting at 12 sites Stimuli Technology · Bron and 16 other locations · NCT07205445

• Sexual problems in women with relapsing-remitting multiple sclerosis

  See if sexual dysfunction is common in women aged 25-50 with relapsing-remitting MS and whether it's linked to fatigue, mood, bladder symptoms, and cognitive problems.

  Recruiting Ege University · Izmir, Bornova · NCT07193823

• At-home tibial nerve stimulation to treat overactive bladder in rural women

  We will test whether a self‑administered at‑home tibial nerve stimulation using a preset TENS unit can reduce overactive bladder symptoms in treatment‑naïve rural women.

  Recruiting Oregon Health and Science University · Portland, Oregon · NCT07178314

• Using sacral nerve responses to guide sacral neuromodulation for overactive bladder

  This research will test whether choosing sacral nerve stimulation settings based on sacral evoked responses versus visual-motor responses helps adults with overactive bladder symptoms.

  Recruiting University of Michigan · Ann Arbor, Michigan · NCT06983470

• Examining changes in the urinary microbiome and metabolome in women with overactive bladder

  This study looks at how the bacteria and substances in the urine of women with overactive bladder change before and after they receive standard treatment to see if these changes relate to their improvement in symptoms.

  Recruiting at 4 sites University Hospital Ostrava · Ostrava, Moravian-Silesian Region and 3 other locations · NCT06921746

• Treatment for male overactive bladder using sacral neuromodulation

  This study is testing a new device to see if it can help men with overactive bladder feel better after prostate surgery or radiation therapy.

  Recruiting at 21 sites Axonics, Inc. · Birmingham, Alabama and 22 other locations · NCT06511141

• Using Botox to treat overactive bladder while preventing urinary tract infections

  This study is testing if Botox injections for overactive bladder can be safely combined with a specific antibiotic to help prevent urinary tract infections in women.

  Recruiting Phase 4 Walter Reed National Military Medical Center · Bethesda, Maryland · NCT06387329

• Shortening the trial time for sacral neuromodulation in treating urinary incontinence

  This study is testing if cutting the trial period for a nerve treatment from 7 days to 3 days can still help women with urinary incontinence feel better before getting a permanent device.

  Recruiting University of Chicago · Chicago, Illinois · NCT06226220

• Using high-dose vitamin D to treat overactive bladder in children

  This study is testing if giving high-dose vitamin D along with regular therapy can help children with wet overactive bladder feel better compared to just therapy or therapy with a medication.

  Recruiting Children's Hospital of Chongqing Medical University · Chongqing, Chongqing Municipality · NCT06201013

• Modulating brain regions to treat bladder issues in multiple sclerosis

  This study is testing whether a new brain stimulation technique can help women with multiple sclerosis who have bladder problems feel better by focusing on the brain instead of just the bladder.

  Recruiting The Methodist Hospital Research Institute · Houston, Texas · NCT06072703

• Evaluating Electroacupuncture for Women with Overactive Bladder

  This study is testing if electroacupuncture can help women with overactive bladder feel better and improve their quality of life.

  Recruiting Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation · New Taipei City · NCT05997992

• Comparing electroacupuncture and medication for treating overactive bladder in women

  This study is testing whether electroacupuncture can help women with overactive bladder feel better compared to the medication Solifenacin.

  Recruiting Shanghai University of Traditional Chinese Medicine · Shanghai, Shanghai Municipality · NCT05798403

• How bladder sensations during filling relate to overactive bladder in people with multiple sclerosis

  We will test whether changes in bladder sensations during filling are linked to overactive bladder symptoms in adults with multiple sclerosis.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris, Choisir Une Région · NCT05772637

• Evaluation of eCoin for treating urgency urinary incontinence

  This study is testing whether an implanted device called eCoin can help people with urgency urinary incontinence feel better over the long term.

  Recruiting at 19 sites Valencia Technologies Corporation · Homewood, Alabama and 21 other locations · NCT05685433

• Noninvasive ultrasound assessment of bladder function

  This study is testing a new ultrasound method to see if it can help identify bladder problems in men with benign prostatic hyperplasia (BPH) and guide their treatment.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT05652023

• Comparing bladder therapies for older women with urinary incontinence

  This study is testing whether two different bladder treatments can help older women with urinary incontinence feel better compared to a placebo.

  Recruiting at 2 sites Phase 4 University of California, San Francisco · Palo Alto, California and 1 other locations · NCT05362292

• PEER 2: Pelvic nerve recording during Medtronic InterStim sacral neuromodulation

  This tests whether recording electrical signals from pelvic nerves during Medtronic InterStim sacral neuromodulation can help guide therapy for adults with overactive bladder, fecal incontinence, or urinary retention.

  Recruiting at 5 sites MedtronicNeuro · Indianapolis, Indiana and 6 other locations · NCT05200923

• Comparing Emsella Chair therapy to a sham treatment for overactive bladder

  This study is testing if the Emsella Chair, a new therapy that uses electromagnetic technology, can help people with overactive bladder feel better compared to a fake treatment.

  Recruiting Corewell Health East · Royal Oak, Michigan · NCT04873037

• Evaluating antibiotic use before onabotulinumtoxinA injections for overactive bladder

  This study is testing if giving antibiotics before onabotulinumtoxinA injections helps or is needed for adults with overactive bladder who haven't found relief from other treatments.

  Recruiting Benaroya Research Institute · Stony Brook, New York · NCT04754737

• Reducing radiation exposure during sacral neuromodulation lead placement

  This study tests if using lower radiation settings during sacral neuromodulation lead placement can help keep patients with overactive bladder safe while still getting the procedure done correctly.

  Recruiting Loma Linda University · Loma Linda, California · NCT04527445

• Comparing standard and reduced injections of onabotulinumtoxinA for overactive bladder treatment

  This study is testing if fewer injections of a bladder treatment can work just as well as the usual number of injections for people with overactive bladder.

  Recruiting Phase 4 Walter Reed National Military Medical Center · Bethesda, Maryland · NCT04020510

NIH-funded research (18)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Microneedle delivery of Trospium for better tolerance in overactive bladder

  A tiny, painless microneedle patch is being developed to deliver Trospium chloride more comfortably for people with overactive bladder.

  NIH research Tsrl, INC. · Ann Arbor, United States · NIH-11416409

• Alternatives to Step Therapy for Overactive Bladder in Older Adults

  This grant explores simpler, patient-centered ways to treat overactive bladder in people 65 and older, to help them get effective care faster.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11406295

• Culturally tailored AI-assisted digital therapy for bladder symptoms in Black women

  A new AI-powered app called CeCe helps Black women learn about overactive bladder and manage its symptoms with education and coaching.

  NIH research Renalis Health INC. · Chicago, UNITED STATES · NIH-11350201

• Predicting risks and outcomes of advanced overactive bladder treatments for older adults

  This project will build a tool to predict which third-line treatments for overactive bladder are likely to help or harm older and frail adults.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11303414

• Personalized brain stimulation for overactive bladder in multiple sclerosis

  This research uses targeted, noninvasive brain stimulation to try to reduce urinary urgency, frequency, and leakage in women with multiple sclerosis.

  NIH research Methodist Hospital Research Institute · Houston, United States · NIH-11249154

• Long-lasting bladder treatment for urinary leaks and urgency in older adults

  This project is creating bladder-instilled medicines that aim to give months of relief from urinary leaks and urgent urges in older adults who haven't been helped by current treatments.

  NIH research Dignify Therapeutics, LLC · Research Triangle Park, United States · NIH-11182543

• Microneedle patch to deliver trospium for overactive bladder

  A tiny microneedle patch that delivers the bladder medicine trospium aims to reduce side effects and improve symptom control for people with overactive bladder.

  NIH research Tsrl, INC. · Ann Arbor, United States · NIH-11180658

• Understanding the causes of overactive bladder through muscle analysis

  This study is looking at how tight pelvic floor muscles might be linked to overactive bladder and chronic pelvic pain, with the goal of finding better ways to treat people who have these issues by understanding their muscle patterns and movements.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11146223

• How stress and anxiety affect overactive bladder

  This project explores whether stress and anxiety make overactive bladder symptoms worse and lead people with OAB to use coping behaviors that reduce quality of life.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11143758

• Understanding treatment outcomes for older adults with overactive bladder

  This study is looking at how older adults with overactive bladder respond to different advanced treatments, like injections and nerve stimulation, to find out what works best for them and to help doctors make better choices for their care.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11073108

• Adapting a digital therapy for overactive bladder in Latina women

  This study is testing a new app called CeCe that helps Latina women with overactive bladder learn about and manage their symptoms in a way that feels familiar and supportive to their culture, aiming to improve their quality of life.

  NIH research Renalis Health INC. · Chicago, UNITED STATES · NIH-11008437

• Investigating brain stimulation to improve bladder control in multiple sclerosis patients

  This study is looking at a new way to help people with multiple sclerosis who have trouble with frequent and urgent urination by using a safe brain stimulation technique to see if it can improve their bladder symptoms.

  NIH research Methodist Hospital Research Institute · Houston, United States · NIH-11001934

• Understanding treatment outcomes for older adults with overactive bladder

  This study is looking at how older adults with overactive bladder respond to new treatments, like injections and nerve stimulation, to find out which options work best and are safest for them, so they can get the right care for their needs.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-10912086

• How stress and anxiety affect overactive bladder symptoms

  This study is looking at how stress and anxiety affect people with overactive bladder (OAB) symptoms, like needing to go to the bathroom often, to help find better ways to manage these issues and improve their quality of life.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-10903961

• Improving access and adherence to overactive bladder treatment using mobile technology and personalized behavior changes.

  This study is looking to help women with overactive bladder by using a mobile app to make it easier for them to understand their condition and stick to their treatment plans, especially for those who might face extra challenges.

  NIH research Stanford University · Stanford, United States · NIH-10893433

• Understanding how central nervous system changes affect overactive bladder symptoms

  This study is looking at how changes in the brain and nervous system might affect people with overactive bladder, which causes a strong need to urinate often, and aims to find better, more personalized treatments by considering both physical and emotional factors.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-10890812

• A new minimally invasive treatment for overactive bladder

  This study is testing a new device called the NewUro Uzap, which provides a quick and gentle treatment for people with overactive bladder to help reduce the urge to urinate and improve their daily life, all without needing medications or surgery.

  NIH research Stellartech Research Corporation · Milpitas, United States · NIH-10874601

• Understanding brain activity during bladder filling to improve overactive bladder diagnosis

  This study is looking at how the brains of people with overactive bladder respond when their bladders fill up, using a special technology to see brain activity, so we can find better ways to understand and treat different types of this condition.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-10474965

Related topics

Quick answers

How many Overactive Bladder clinical trials are recruiting right now?

25, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 8 countries. The most sites are in United States (18 trials), China (2 trials), France (2 trials), Turkey (Türkiye) (1 trial), Italy (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 3, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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