Enhanced patient-reported tools to guide easy, real-time decisions for benign prostatic hyperplasia
Official title: Enhanced Clinical Decisions for Management of Benign Prostatic Hyperplasia Using Patient-Reported Outcomes
Funded at University of Chicago · NIH-11416370 · Data updated 2026-11-12
A clinical project will use patient-reported symptom surveys to help doctors choose the best treatments for men with benign prostatic hyperplasia.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | June 1, 2025 |
| Project end | May 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $573,274 |
| NIH project number | 5R01DK130963-05 |
| Project ID | NIH-11416370 on NIH RePORTER |
Who could benefit from this research
✓Could help
Men with benign prostatic hyperplasia who are undergoing evaluation or management in urology clinics and are able to complete PRO questionnaires.
✕Less likely to help
Patients with BPH who are not engaged with symptom reporting or unable to complete PROs may see limited benefit.
What this research studies
This project aims to replace or augment the traditional symptom checklists with broader, multidimensional PROs to capture urinary symptoms more completely. It will integrate these PROs into routine care and electronic health records to support timely decisions. The study will identify what PRO score changes are meaningful for patients and develop care recommendations to match treatments to individual needs.
Why it matters
Potential benefit: If successful, patients with BPH could receive more personalized and timely treatment choices based on their own symptom reports.
How similar studies have gone: Previous PRO tools were not fully validated for BPH; this project builds on LURN instruments to tailor to BPH populations.
Where this research is happening
-
University of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Griffith, James William — University of Chicago
- Study coordinator: Griffith, James William
Related research
Other NIH-funded projects on the same topics.
-
Fat-rich TREM2+ immune cells that may drive an enlarged prostate
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Noninvasive treatment for enlarged prostate tissue
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Sonablate HIFU Registry for Prostate Cancer and BPH
This registry collects real-world data from men treated with Sonablate HIFU to see how well it works and how it affects urinary and sexual function over the long term.
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This study tests whether adding tadalafil to tamsulosin helps men with BPH see better urinary symptoms and quality of life, using two tadalafil doses over 12 weeks.
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MRI-DTI look at the urethral sphincter ring and prostate base shape
This imaging study tests how the male urethral internal sphincter ring appears on MRI-DTI and how it relates to prostate base morphology in men undergoing clinically indicated MRI.
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Tamsulosin With or Without Tadalafil for a Trial Without Catheter After Acute Urinary Retention
This study tests whether adding tadalafil to tamsulosin helps men with a first episode of acute urinary retention due to enlarged prostate pass urine without needing a catheter.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.