ESPB for persistent back pain in ankylosing spondylitis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The study investigates the analgesic effect of the erector spinae plane block (ESPB) in adults with ankylosing spondylitis and ongoing back pain despite treatment aimed at controlling disease activity. Participants receive ESPB as an interventional approach to pain management while continuing standard medical therapy. The trial will assess changes in pain severity and key clinical outcomes over a defined follow-up period. This is one of the first evaluations of ESPB specifically in AS patients with residual pain on treatment. The study is conducted at Marmara University in Istanbul and aims to address unmet need for additional pain relief in this population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age between 18 and 65 years
* Diagnosis of ankylosing spondylitis according to the Modified New York Criteria
* Patients receiving ongoing treatment with controlled disease activity but persistent back pain
* Willingness to participate in the study

Exclusion Criteria:

* Body mass index (BMI) greater than 35 kg/m²
* History of thoracic surgery
* Intellectual disability or mental retardation
* Presence of major psychiatric comorbidity
* Congenital spinal anomaly
* Pregnancy
* History of bleeding diathesis
* Presence of active local and/or systemic infection
* Known allergy to the medications to be injected
* Hemodynamic instability
* Active phase of the disease (elevated acute phase reactants, active arthritis findings, etc.)

Where it's running

• Marmara University Faculty of Medicine Pendik Training and Research Hospital
  Istanbul, Pendik, Turkey (Türkiye) Recruiting

Study contacts

• Principal investigator: Fatma B Akdağ, Research Assistant — Marmara University Faculty of Medicine ,Marmara University, Department of Physical Medicine and Rehabilitation
• Study coordinator: Fatma B Akdağ, Research Assistant
• Email: fatma.betul820@gmail.com
• Phone: +90 537 452 96 60

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• MST-931 in healthy adults

  This early-phase study tests a single subcutaneous dose of MST-931 to see if it is safe and how it behaves in the body in healthy adults.

  Recruiting Phase 1 Mabsoft Therapeutics (Shanghai) Co., Ltd. · Herston, Queensland · NCT07903493

• Lateral Quadratus Lumborum Block vs Intrathecal Morphine for Cesarean Section analgesia

  This study tests whether a lateral quadratus lumborum block can provide pain relief after cesarean delivery as effectively as intrathecal morphine.

  Recruiting Ondokuz Mayıs University · Samsun · NCT07712783

• Impact of Communication Delays on Anesthesia Response in Medical Emergencies and Ultrasound-Guided Nerve Blocks

  This study tests how an 80-second communication delay affects the speed and quality of regional anesthesia nerve blocks during emergencies in a spaceflight-like setting.

  Recruiting Nova Scotia Health Authority · Halifax, Nova Scotia · NCT07675863

• Erector Spinae Plane Block vs Trigger Point Injection for Chronic Thoracic Myofascial Pain

  A randomized trial tests whether an erector spinae plane (ESP) block or a trigger point injection (TPI) provides better relief for adults with chronic thoracic myofascial pain.

  Recruiting Phase 4 Mayo Clinic · Jacksonville, Florida and 4 other locations · NCT07632820

• Effect of smartphone use on neck posture and function in RA/AS patients and healthy controls

  This study tests how smartphone use relates to neck posture, tongue pressure, balance, and neck-related disability in people with rheumatoid arthritis or ankylosing spondylitis compared with healthy individuals.

  Recruiting Necmettin Erbakan University · Konya, Meram · NCT07627542

• Comparison of meta-PENG vs suprainguinal fascia iliaca block for hip fracture pain

  This study tests whether two ultrasound-guided nerve blocks help with pain control for adults having hip fracture surgery under spinal anesthesia.

  Recruiting Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital · Istanbul, Istanbul · NCT07612761

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.