Understanding how work-related exposures and genetics affect ALS risk
RFA-TS-23-001: Establishing the Cohort for Occupational Risk and Prevention Studies for Amyotrophic Lateral Sclerosis (ALS CORPS)
This study is looking for people who might be at a higher risk for ALS because of their jobs, especially those in production and metal work, to see how their work and genetics might affect their chances of developing the disease over time.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10909768 on NIH RePORTER |
What this research studies
This research aims to establish a cohort of individuals who are at higher risk for amyotrophic lateral sclerosis (ALS) due to their occupational exposures, particularly in production jobs and metal exposure. By monitoring these individuals over time, the study will investigate how these non-genetic factors interact with genetic predispositions to influence the onset of ALS. Participants will provide valuable data that could help identify cumulative risk factors for ALS and inform prevention strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who work in production occupations or have had significant exposure to occupational metals and are concerned about their risk for ALS.
Not a fit: Patients who do not have occupational exposure to metals or who are not in high-risk occupations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention strategies for ALS, potentially reducing the incidence of this devastating disease.
How similar studies have performed: Previous research has indicated a strong association between occupational exposures and ALS risk, suggesting that this approach could yield meaningful insights.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Goutman, Stephen — University of Michigan at Ann Arbor
- Study coordinator: Goutman, Stephen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.