Influence of Smell and Taste on Nutrition in ALS Patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates how sense of smell and taste relate to the nutritional status of adults diagnosed with ALS. Participants are adults with definite or probable ALS seen at a regional center in Dijon, France. The study collects information on sensory changes and nutritional outcomes to understand potential links between chemosensory function and dietary intake in ALS. Enrollment requires French fluency, consent, and certain clinical criteria, with exclusions for conditions that affect swallowing or overall ability to participate. Findings may help tailor nutritional support for ALS patients if chemosensory factors influence intake.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Inclusion criteria\*:

* Incident cases of definite or probable ALS according to El-Escorial criteria (3) followed up at the participating regional centre of competence
* Patient aged over 18
* Patient fluent in French
* Patient having given oral consent

Exclusion Criteria:

* Patients with an acute infection undergoing antibiotic treatment at the time of inclusion
* Patients with psychiatric, cognitive or neurological disorders making it impossible to assess food preferences
* Patient with a known food allergy
* Patients with excessive alcohol consumption (≥ 10 standard drinks per week)
* Patients who have stopped smoking for less than 1 month
* Patients with severe bulbar involvement from the outset, preventing swallowing, patients with aphagia or patients eating exclusively via a gastrostomy
* Patient with severe diaphragmatic impairment requiring NIV from the outset
* Person not affiliated to or not benefiting from a social security scheme
* Person under legal protection (curatorship, guardianship)
* Persons subject to a legal protection measure
* Pregnant women, women in labour or breastfeeding mothers
* An adult who is incapable or unable to give consent
* Minors

Where it's running

• Chu Dijon Bourgogne
  Dijon, France Recruiting

Study contacts

• Study coordinator: Marjolaine GEORGES
• Email: marjolaine.georges@chu-dijon.fr
• Phone: 0380293772

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.