Condition
Primary Lateral Sclerosis (PLS) clinical trials and research
As of November 12, 2026, Find a Trial lists 3 Primary Lateral Sclerosis (PLS) clinical trials that are recruiting, in United States. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 3Clinical trials
- 1Country
Newest Primary Lateral Sclerosis (PLS) clinical trials
| Study | Phase | Where | Status | Registered |
|---|---|---|---|---|
| Biomarker Repository for Age-Related and Inherited Neurodegenerative Diseases | — | Philadelphia, Pennsylvania | Recruiting | Sep 1, 2026 |
| Healing ALS Registry (HAROS) for people with ALS, MND, and PLS | — | Park City, Utah | Recruiting | Nov 18, 2025 |
| Electrical stimulation to reduce facial pain and improve jaw movement and chewing in people with motor neuron disease | — | Davie, Florida | Recruiting | Sep 23, 2025 |
All recruiting trials (3)
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Biomarker Repository for Age-Related and Inherited Neurodegenerative Diseases
This study collects blood and genetic samples from people with neurodegenerative diseases and their families to build a shared resource for studying disease risk and biology.
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Healing ALS Registry (HAROS) for people with ALS, MND, and PLS
This fully remote registry asks people with ALS, MND, or PLS to enter monthly health, treatment, and lifestyle information to try to see which therapies and education relate to better physical outcomes.
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Electrical stimulation to reduce facial pain and improve jaw movement and chewing in people with motor neuron disease
This trial will try one 30-minute session of non-invasive facial electrical stimulation to see if it reduces jaw and facial pain and improves chewing and jaw movement for people with ALS or PLS.
Related topics
Quick answers
How many Primary Lateral Sclerosis (PLS) clinical trials are recruiting right now?
3, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
All of them have sites in United States. Each study page lists its sites and which ones are recruiting.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.