Improving motor function in ALS patients using pulse stimulation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to evaluate the effectiveness of Transcranial Pulse Stimulation (TPS) on motor function in individuals diagnosed with Amyotrophic Lateral Sclerosis (ALS). The study is divided into two stages: the first stage assesses changes in short intracortical inhibition of the motor cortex over eight weeks, while the second stage compares the effects of TPS versus sham stimulation on the ALS functional rating scale over six months. Participants will be monitored for changes in biomarkers and clinical endpoints to determine the efficacy of the treatment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients with diagnosis of sporadic ALS (definite or clinically probable) as defined by the World Federation of Neurology revised El Escorial criteria
* SVC of 50% or greater of estimated measure and presence of measurable motor evoked potential
* 21 to 80 years old and male or female

Exclusion Criteria:

* patients with fALS (based on medical history) that are unable to tolerate TMS and MRI studies or have a contraindication as described below

Where it's running

• Hospital del Mar
  Barcelona, Catalonia, Spain Recruiting

Study contacts

• Study coordinator: Alba Leon, MD
• Email: aleonjorba@psmar.cat
• Phone: +34932 48 30 00

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.