Plasmapheresis for ALS with anti-NRIP autoantibody

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a single-arm clinical trial enrolling about 20 adults with ALS who test positive for anti-NRIP autoantibody. Participants will receive three plasmapheresis treatments every three months, with follow-up for six more months to monitor safety and antibody levels as well as motor function. The goal is to see if reducing the anti-NRIP autoantibody in blood correlates with better clinical outcomes and tolerability. Results will help determine if plasmapheresis is a viable approach for this ALS subtype. The study is conducted at National Taiwan University Hospital and is led by its investigators.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* ALS patients above 20-year-old who have anti-NRIP autoantibody in plasma
* Agree to receive plasmapheresis treatment
* Agree to participate in the study and receive serial examinations

Exclusion Criteria:

* Under permanent ventilator support
* Cannot receive plasmapheresis treatment or serial examinations
* Under pregnancy
* Blood fibrinogen level below 50 mg/dl
* Belong to special subtype of ALS, such as primary lateral sclerosis, progressive muscular atrophy, flail arm syndrome, flail leg syndrome.

Where it's running

• National Taiwan University Hospital
  Taipei City, Taipei, Taiwan Recruiting

Study contacts

• Study coordinator: Li-Kai Tsai, MD, PhD
• Email: milikai@ntuh.gov.tw
• Phone: +886972651560

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.