Developing new medications to help reduce alcohol dependence
Fragment-based Discovery of COMT Inhibitors as a Novel Pharmacotherapy for Alcoholism
This study is looking for new medications that can help people reduce their drinking by targeting a specific enzyme in the brain, and if successful, these treatments could offer a safer option for those struggling with alcohol use disorder.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10850909 on NIH RePORTER |
What this research studies
This research focuses on finding new inhibitors of the enzyme COMT, which plays a role in regulating neurotransmitters related to alcohol use disorder (AUD). By using a novel drug discovery approach, the team aims to create medications that can effectively reduce alcohol consumption without the harmful side effects associated with existing treatments. The research will involve testing these new compounds in animal models to assess their effectiveness in reducing alcohol intake and improving cognitive functions. Patients may benefit from these new therapies if they are successful in clinical applications.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with alcohol use disorder who are seeking new treatment options.
Not a fit: Patients who do not have alcohol use disorder or those who are not seeking treatment for alcohol dependence may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective treatments for individuals struggling with alcohol dependence.
How similar studies have performed: Previous research has shown that existing COMT inhibitors can reduce alcohol consumption, indicating potential for success with this novel approach.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Cohen, Seth M — University of California, San Diego
- Study coordinator: Cohen, Seth M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.