Investigating how brain cells respond to alcohol dependence
6/11 Astrocyte-specific changes and interventions in alcohol dependence
This study is looking at how brain cells called astrocytes change when someone has an alcohol use disorder, and it hopes to find out if changing a specific gene can help reduce drinking and improve brain health.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-11014323 on NIH RePORTER |
What this research studies
This research focuses on understanding the changes in specific brain cells called astrocytes in response to alcohol use disorder. It examines how these cells alter their gene expression and immune responses when exposed to alcohol over time. The study aims to identify the molecular mechanisms involved and whether targeting a specific gene can reduce alcohol consumption and related neuroimmune responses. By using animal models, researchers will explore the effects of chronic alcohol exposure on astrocyte behavior and brain function.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals struggling with alcohol use disorder or those who have a history of alcohol dependence.
Not a fit: Patients who do not have issues with alcohol consumption or those with other unrelated neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that help reduce alcohol dependence and improve brain health.
How similar studies have performed: Previous research has shown promising results in understanding the role of astrocytes in alcohol dependence, suggesting that this approach could yield valuable insights.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Guizzetti, Marina — Oregon Health & Science University
- Study coordinator: Guizzetti, Marina
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.