How oxytocin and stress hormones affect alcohol dependence
Opposing Contributions of Oxytocin and Corticotropin-Release Factor to Alcohol Dependence
This study is looking at how two brain chemicals, oxytocin and CRF, affect drinking habits in people who struggle with alcohol dependence, to find out how oxytocin might help reduce stress-related drinking and lead to better treatments for those dealing with this issue.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tennessee Health Sci Ctr NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-10655413 on NIH RePORTER |
What this research studies
This research investigates the roles of oxytocin and corticotropin-releasing factor (CRF) in alcohol dependence, focusing on how these neuropeptides influence compulsive drinking behaviors. The study aims to identify the brain mechanisms through which oxytocin can counteract the stress-induced drinking patterns associated with alcohol use disorder. By utilizing advanced techniques and training at the National Institute on Drug Abuse, the research will explore the neuronal circuitry involved in these processes, potentially leading to new treatment strategies for individuals struggling with alcohol dependence.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with alcohol use disorder who experience compulsive drinking behaviors.
Not a fit: Patients who do not have alcohol use disorder or those who are not actively engaged in alcohol consumption may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for alcohol use disorder, helping patients reduce their compulsive drinking behaviors.
How similar studies have performed: Previous research has shown promising results in using oxytocin to reduce compulsive drinking in animal models, suggesting potential for success in human applications.
Where this research is happening
Memphis, United States
- University of Tennessee Health Sci Ctr — Memphis, United States (Active)
Researchers
- Principal investigator: Tunstall, Brendan — University of Tennessee Health Sci Ctr
- Study coordinator: Tunstall, Brendan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.