Investigating how vasopressin affects pain and alcohol dependence
Official title: Vasopressin Signaling in Pain and Alcohol Dependence
Funded at Lsu Health Sciences Center · NIH-10441221 · Data updated 2026-11-12
This study looks at how feelings of pain and negative emotions can affect drinking habits in people with alcohol use disorder, using animal models to see how a specific brain chemical might play a role, with the hope of finding better treatments for those dealing with both chronic pain and alcohol issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lsu Health Sciences Center NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project start | August 10, 2018 |
| Project end | June 30, 2025 |
| Funding year | 2022 |
| Award (this year) | $330,750 |
| NIH project number | 5R01AA025996-05 |
| Project ID | NIH-10441221 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing alcohol use disorder, particularly those also suffering from chronic pain.
✕Less likely to help
Patients who do not have alcohol use disorder or chronic pain may not benefit from this research.
What this research studies
This research explores the relationship between pain and alcohol use disorder (AUD), focusing on how negative emotional states can influence alcohol consumption. The study uses animal models to examine the effects of vasopressin, a neuropeptide, on pain sensitivity and drinking behavior. By understanding the neuropharmacological mechanisms involved, the research aims to identify potential treatments for individuals suffering from both chronic pain and AUD.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for patients dealing with alcohol dependence and chronic pain.
How similar studies have gone: Previous research has shown promising results with vasopressin antagonists in reducing excessive drinking and stress-induced hyperalgesia, indicating potential for success in this area.
Where this research is happening
-
Lsu Health Sciences Center
New Orleans, United States Active
Researchers
- Principal investigator: Edwards, Scott — Lsu Health Sciences Center
- Study coordinator: Edwards, Scott
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.