Investigating how glucocorticoid receptors affect alcohol dependence
Role of glucocorticoid receptor-mediated mRNA decay in alcohol dependence
['FUNDING_R21'] · SCRIPPS RESEARCH INSTITUTE, THE · NIH-10931639
This study is looking at how blocking certain receptors in the brain might help people who struggle with alcohol dependence by reducing their cravings and drinking, and it’s aimed at finding better ways to treat alcohol use disorders.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SCRIPPS RESEARCH INSTITUTE, THE (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-10931639 on ClinicalTrials.gov |
What this research studies
This research explores the role of glucocorticoid receptors in alcohol dependence, focusing on how their inhibition can reduce alcohol intake and cravings. The study will examine the molecular mechanisms behind this effect, particularly the process of glucocorticoid receptor-mediated mRNA decay, which may influence alcohol consumption behaviors. By analyzing brain samples from mice, the researchers aim to identify specific mRNAs affected by glucocorticoid receptor activity during alcohol withdrawal. This could lead to a better understanding of how to treat alcohol use disorders effectively.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of alcohol use disorder who are currently abstinent or undergoing withdrawal.
Not a fit: Patients who do not have alcohol use disorder or are not experiencing withdrawal symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating alcohol dependence.
How similar studies have performed: Previous studies have shown that glucocorticoid receptor inhibition can effectively reduce alcohol intake, suggesting that this approach has potential for success.
Where this research is happening
LA JOLLA, UNITED STATES
- SCRIPPS RESEARCH INSTITUTE, THE — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CONTET, CANDICE — SCRIPPS RESEARCH INSTITUTE, THE
- Study coordinator: CONTET, CANDICE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alcohol withdrawal syndrome