Condition

Hepatitis B, Chronic clinical trials and research

• 17Clinical trials
• 17Countries

Newest Hepatitis B, Chronic clinical trials

All recruiting trials (17)

• AHB-137 for chronic hepatitis B in adults on nucleotide analogue therapy

  AHB-137 is being tested to see if it is safe and effective for adults with chronic hepatitis B who are currently on nucleos(t)ide analogue therapy.

  Recruiting Phase 2 AusperBio Therapeutics Inc. · Redwood City, California and 9 other locations · NCT07654283

• Oral and gum health and saliva markers in people with hepatitis B and D

  This project will test whether gum inflammation and specific saliva and gum-fluid markers differ in adults with hepatitis B and D—both those taking bulevirtide and those not—compared with healthy adults.

  Recruiting at 2 sites Research Center of Periodontal-Systemic Interactions · Craiova and 1 other locations · NCT07491848

• Entecavir Resistance Mutations in chronic hepatitis B patients in Turkey

  This study tests whether entecavir resistance mutations can be detected in adults with chronic hepatitis B, and whether prior lamivudine exposure increases the chance of those mutations appearing.

  Recruiting at 2 sites Guven Health Group · Adana and 9 other locations · NCT07459426

• AHB-137 for HBeAg-negative chronic hepatitis B in the Asia–Pacific

  This trial tests whether AHB-137 injections can improve outcomes for adults in the Asia–Pacific with HBeAg-negative chronic hepatitis B who are already on nucleos(t)ide therapy.

  Recruiting at 9 sites Phase 2 AusperBio Therapeutics Inc. · Fitzroy, Victoria and 9 other locations · NCT07370207

• Sequential PEG-IFN for Hepatitis B After RNA-targeted Therapy

  This study tests whether starting or delaying a 24-week course of pegylated interferon helps people with chronic hepatitis B who previously used ASO/siRNA therapies.

  Recruiting at 2 sites Huashan Hospital · Beijing, China and 1 other locations · NCT06923280

• Evaluating a new gene therapy for chronic hepatitis B

  This study is testing a new gene therapy for adults with chronic hepatitis B to see if it is safe and effective in fighting the virus.

  Recruiting at 7 sites Phase 1 Precision BioSciences, Inc. · Boston, Massachusetts and 6 other locations · NCT06680232

• Detecting HBsAg Reversion in Hepatitis B Patients

  This study is testing how well a new blood test can find if hepatitis B patients who have stopped treatment might have their virus levels come back after being cleared.

  Recruiting Huashan Hospital · Shanghai, Shanghai Municipality · NCT06550622

• Observational study of immune status in chronic hepatitis B patients

  This study looks at the immune health of people with chronic hepatitis B to see how it varies in those who are untreated and those who have successfully lowered the virus with medication.

  Recruiting at 2 sites Tongji Hospital · Wuhan, Hubei and 4 other locations · NCT06525909

• Testing a new drug for chronic hepatitis B infection

  This study is testing a new drug called VIR-3434 to see if it can help people with chronic hepatitis B infection improve their condition over a year of treatment.

  Recruiting Phase 2 University Health Network, Toronto · Toronto, Ontario · NCT06216470

• Follow-up of patients with decreased HBsAg levels in chronic hepatitis B

  This study is tracking people with chronic hepatitis B who have lower HBsAg levels to see how their treatment affects their condition over three years.

  Recruiting Nanfang Hospital, Southern Medical University · Guangzhou, Guangdong · NCT05977283

• Observing antiviral treatment strategies for chronic hepatitis B in real-world settings

  This study looks at how well different antiviral treatments for chronic hepatitis B work in everyday medical settings for adults aged 18 to 80.

  Recruiting at 3 sites Huashan Hospital · Hefei, Anhui and 43 other locations · NCT05937178

• Comparing continuous and pulsed treatment for chronic hepatitis B

  This study is testing whether a continuous or pulsed treatment using a combination of medications can help people with chronic hepatitis B get better results.

  Recruiting Early Phase 1 Anhui Medical University · Hefei, Anhui · NCT05922306

• Improving early diagnosis of liver cancer in high-risk patients in China

  This study is testing if regular check-ups for liver cancer can help catch the disease earlier in people at high risk due to conditions like chronic hepatitis or cirrhosis in China.

  Recruiting Ruijin Hospital · Shanghai, Shanghai Municipality · NCT05870969

• Treatment for inactive chronic hepatitis B patients

  This study is testing if a new treatment called Peginterferon Alfa-2B can help adults with inactive chronic hepatitis B achieve a functional cure.

  Recruiting Phase 4 Third Affiliated Hospital, Sun Yat-Sen University · Guangzhou, Guangdong · NCT05182463

• Combining DPMAS and Low Volume Plasma Exchange for Hepatitis B Related Liver Failure

  This study is testing a new treatment combining a special blood filtering system and plasma exchange to see if it helps people with liver failure caused by hepatitis B feel better and improve their health.

  Recruiting Third Affiliated Hospital, Sun Yat-Sen University · Guangzhou, Guangdong · NCT04597164

• Observational study of patients co-infected with Hepatitis B and Delta viruses

  This study looks at patients who have both Hepatitis B and Delta viruses to see how their treatment affects their health over time.

  Recruiting at 36 sites ANRS, Emerging Infectious Diseases · Angers and 37 other locations · NCT04166266

• Observational study on chronic Hepatitis B infection in Jiangsu

  This study is collecting information from people with chronic Hepatitis B in Jiangsu, China, to see what factors might affect their health outcomes.

  Recruiting at 6 sites The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School · Changzhou, Jiangsu and 5 other locations · NCT03097952

Related topics

Quick answers

How many Hepatitis B, Chronic clinical trials are recruiting right now?

17, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 17 countries. The most sites are in China (11 trials), France (3 trials), Canada (2 trials), United States (2 trials), New Zealand (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 3, Early Phase 1: 1, Phase 4: 1, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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