Comparing spironolactone and doxycycline for treating acne in women
A randomized, double-blind, multi-center comparative effectiveness study of spironolactone versus doxycycline hyclate for the treatment of acne in women
This study is looking at how well two medications, spironolactone and doxycycline, work for treating moderate to severe acne in women, and by joining, you could help find out which one might be better for your skin!
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10699996 on NIH RePORTER |
What this research studies
This research investigates the effectiveness of two medications, spironolactone and doxycycline, in treating moderate to severe acne in women. Participants will be randomly assigned to receive one of the two treatments in a double-blind manner, meaning neither the participants nor the researchers will know which treatment is being administered. The study aims to determine which medication is more effective and to assess their impact on the skin microbiome. By participating, women with acne may contribute to important findings that could influence future treatment options.
Who could benefit from this research
Good fit: Ideal candidates for this research are women aged 21 and older who are experiencing moderate to severe acne.
Not a fit: Patients with mild acne or those who are not women may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide clearer guidance on the most effective treatment for acne in women, potentially leading to better management of the condition.
How similar studies have performed: Previous research has highlighted the need for comparative effectiveness studies in acne treatment, indicating that this approach is both relevant and necessary.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Margolis, David — University of Pennsylvania
- Study coordinator: Margolis, David
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.