Understanding how immune responses affect acne
Official title: Th17 extracellular trap-mediated antimicrobial host defense in acne vulgaris
Funded at University of California Los Angeles · NIH-10880415 · Data updated 2026-11-12
This study is looking at how certain immune cells in your skin interact with the bacteria that causes acne, to find out how they can help clear up breakouts or make them worse, with the hope of discovering new ways to treat acne more effectively.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | September 6, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $411,954 |
| NIH project number | 5R01AR081337-03 |
| Project ID | NIH-10880415 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from moderate to severe acne vulgaris.
✕Less likely to help
Patients with mild acne or those who do not have acne vulgaris may not benefit from this research.
What this research studies
This research investigates the role of specific immune cells in acne vulgaris, focusing on how the bacteria Cutibacterium acnes interacts with the immune system. The study aims to identify different types of immune cells that can either help fight acne or contribute to its persistence. By analyzing skin samples from patients, researchers will explore how these immune responses can be influenced and potentially lead to new treatments. The goal is to uncover mechanisms that could help in developing therapies that target the immune system to better manage acne.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that more effectively manage acne by targeting immune responses.
How similar studies have gone: Previous research has shown promising results in understanding immune responses in skin conditions, suggesting potential for success in this area.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Agak, George W — University of California Los Angeles
- Study coordinator: Agak, George W
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.