Engineered Lactobacillus reuteri cream with zinc sulfate–tannic acid MPN coating for acne

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This Phase 2 interventional trial applies a topical engineered Lactobacillus reuteri formulation with an MPN zinc sulfate–tannic acid coating and compares it to plain Lactobacillus reuteri cream, a petrolatum-glycerin vehicle, and tretinoin 0.1% cream. Participants who meet inclusion criteria receive one of the topical treatments and are followed over a defined treatment period with clinical acne grading and lesion counts. The study also examines changes in the skin microbiome to determine whether shifting microbial balance correlates with clinical response. Safety, tolerability, and local skin effects are monitored throughout the trial.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Subjects must be diagnosed with acne (based on history, clinical manifestation, and dermatoscopy) and classified as Grade I to III per the International Improved Grading System.
2. Subjects must be willing and able to provide written informed consent.
3. Subjects must be 18 to 33 years of age and in generally good health.
4. Subjects must have more than 9 inflammatory lesions.

Exclusion Criteria:

1. Have used antibiotics within 1 month before the study start.
2. Have used systemic retinoid therapy within 3 months before the study start.
3. Have undergone any other acne treatment within 1 month before the study start.
4. Have any other condition that the investigator considers would make participation unsuitable (e.g., deemed unreliable, non-compliant, or unable to comprehend the study assessments).

Where it's running

• Shenzhen People's Hospital
  Shenzhen, Guangdong, China Recruiting

Study contacts

• Study coordinator: Jianglin Zhang
• Email: zhang.jianglin@szgospital.com
• Phone: +86 13873143466

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.