Understanding how bacteria, fat metabolism, and the immune system contribute to acne
Acne: a disease of lipid metabolism, microbiome and the immune response
This study is looking at how the bacteria on your skin, the fats in your body, and your immune system all work together to cause acne, using skin samples to find out which cells and bacteria are involved, so we can better understand and treat this common skin condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10913491 on NIH RePORTER |
What this research studies
This research investigates the complex interactions between the skin microbiome, lipid metabolism, and the immune response in acne development. By analyzing acne biopsy specimens, scientists will explore how specific immune cells and bacteria contribute to the condition. The study utilizes advanced techniques like single-cell RNA sequencing to identify key cellular players involved in acne pathology. The goal is to develop a comprehensive model that explains how these factors work together to cause acne.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing moderate to severe acne who are willing to provide biopsy samples.
Not a fit: Patients with mild acne or those who do not have acne may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that target the underlying causes of acne rather than just the symptoms.
How similar studies have performed: Previous research has shown promising results in understanding the role of the microbiome and immune response in skin conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Modlin, Robert L — University of California Los Angeles
- Study coordinator: Modlin, Robert L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.