Sponsor or institution
Clinical trials and research at University of Toledo Health Sci Campus
As of November 12, 2026, Find a Trial lists 64 NIH-funded research projects at this institution, with $28.6 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 64NIH research projects
NIH-funded research (newest 40 of 64)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Understanding how ultra-potent opioids harm and how to reverse effects beyond traditional antidotes
Researchers are studying why some extremely strong synthetic opioids cause life-threatening effects and how to counter them, including situations where standard antidotes don’t work well.
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Platform to Target and Degrade Disease-Causing Proteins
A new approach uses smart molecules to degrade harmful proteins that traditional drugs can’t touch, potentially benefiting people with diseases linked to those proteins.
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Mitochondrial DNA and inflammation in back disc degeneration
A study to understand how damaged mitochondrial DNA may trigger inflammation and contribute to disc degeneration in adults.
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Lyme disease vaccine research aimed at preventing infection
Researchers are developing a Lyme disease vaccine by studying how the immune system responds to Borrelia burgdorferi and testing vaccine approaches to prevent illness.
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Dissecting how TNBC tumors suppress the immune system using myeloid cells
This NIH grant explores how a protein called TAZ helps triple-negative breast cancer evade the immune system, with the goal of improving treatments for patients with this aggressive cancer.
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Exosome-based delivery to target pancreatic cancer cells
A patient-friendly look at a project that aims to use tiny natural vesicles to carry cancer-fighting therapies directly to pancreatic tumors.
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New GLT-1 Activators to Help People with Alcohol Dependence
A new preclinical study tests novel drugs that boost a brain transporter to reduce drinking and relapse in alcohol-related conditions.
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Kidney health panel to guide blood pressure treatment in resistant hypertension
A study to test a urine-based kidney health panel that helps doctors tell the difference between real kidney injury and normal kidney changes when treating people with resistant high blood pressure.
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Cross-platform study of bath salts targets and toxicity in humans
A research project aims to map how psychoactive bath salts affect the brain and body, using human-relevant approaches to better understand harmful effects and potential treatments.
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Conjugated bile acids as natural antihypertensive helpers
Researchers are studying whether certain gut-made bile acids can help control high blood pressure in a rat model that mimics human hypertension.
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GSK3beta’s role in diabetic kidney disease and protecting kidney cells
This grant looks at how a molecule called GSK3beta affects kidney damage in people with diabetes and whether targeting it can protect kidney cells.
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Understanding how active protein kinases drive Alzheimer’s dementia
A team is studying how the activity of protein kinases affects the progression of Alzheimer’s dementia using advanced protein-focused methods.
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Early-life pyrethroid pesticide exposure and autism risk
This project will see how exposure to a common pesticide during early development changes brain chemistry and social behaviors linked to autism.
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How serotonin affects brain changes during adolescence and anxiety management
This study is looking at how serotonin affects the teenage brain, especially in a part that helps control fear and anxiety, to find new ways to help young people with anxiety who might not feel better with usual treatments.
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Silencing DSTYK to improve chemotherapy for triple-negative breast cancer
Seeing if turning off a protein called DSTYK helps chemotherapy kill triple-negative breast cancer cells.
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How prenatal disruption of day–night cycles may raise risk for later substance use
This project tests whether being exposed before birth to disrupted day–night cycles makes people more likely to develop substance use or mood problems as they grow up.
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How neutrophil traps (NETs) and the PAD4 enzyme affect gut healing in IBD
Researchers are looking at whether the enzyme PAD4 and the neutrophil traps it creates help protect the gut in people with Crohn’s disease or ulcerative colitis.
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Improving chemotherapy effectiveness in aggressive breast cancer by targeting a specific protein
This study is looking at how turning off a protein called DSTYK might help make chemotherapy work better for people with triple-negative breast cancer, and it aims to find new ways to do this using tiny particles called exosomes.
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Insulin problems in brain support cells linked to delayed puberty and low reproductive hormones
This work looks at whether insulin resistance in brain support cells called astrocytes leads to delayed puberty and low reproductive hormones that can cause infertility.
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Blocking a cancer enzyme (FASN) to help PARP drugs work better in triple-negative breast cancer
This project tries blocking the enzyme FASN to help PARP inhibitor drugs work better for people with triple-negative breast cancer, including those with BRCA changes.
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Examining how disruptions in sleep patterns during pregnancy affect substance use in offspring
This study looks at how changes in sleep patterns during pregnancy, like those caused by shift work, might affect kids later in life, especially regarding their chances of developing substance use issues, and it aims to find ways to help families impacted by these changes.
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How triple-negative breast tumors shut down immune cells
Researchers are seeing how a tumor protein called TAZ causes immune-suppressing cells to gather in triple-negative breast cancer to find ways to improve immune-based treatments for patients.
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Understanding the complex protein networks involved in Alzheimer's dementia.
This study is looking at how certain proteins work together in the brain to help us understand Alzheimer's better, with the hope of finding new ways to treat this challenging disease.
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Gut–brain link in Parkinson's disease
This project looks at whether changes in the gut and a nerve connection to the brain lead to Parkinson's disease and its common bowel symptoms in people with Parkinson's.
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Targeted exosome therapy for pancreatic cancer
Researchers are developing engineered exosomes that latch onto pancreatic cancer cells and avoid immune clearance to deliver drugs more effectively for people with pancreatic ductal adenocarcinoma (PDAC).
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Blocking eIF4A1 to overcome drug-resistant triple-negative breast cancer
This project tests whether stopping a protein called eIF4A1 can weaken drug-resistant breast cancer stem cells in people with aggressive triple-negative breast cancer.
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Bile Acids and Blood Pressure Control
This project explores how certain bile acids, influenced by gut bacteria, might help manage high blood pressure.
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Investigating pathways involved in liver disease related to alcohol use
This study is looking at how specific cellular pathways related to alcohol use can cause liver damage and inflammation, with the goal of finding new treatments that could help people with alcohol-related liver disease feel better.
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Understanding a protein in diabetic kidney disease
This research aims to understand how a specific protein called GSK3beta contributes to diabetic kidney disease, hoping to find new ways to protect the kidneys.
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A urine test to monitor kidney health during hard-to-treat high blood pressure
A urine-based kidney tubule health panel is being tested to help adults with resistant high blood pressure and kidney test changes stay on effective blood pressure medicines.
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Understanding how 'bath salts' affect the body and cause harm
This work aims to understand how different types of 'bath salts' affect the brain and body at a molecular level to help develop better treatments for substance abuse.
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How aging affects bone cell energy and function
This study is looking at how a protein called PPARG affects the energy and health of bone cells as we get older, with the goal of finding ways to keep our bones strong and healthy as we age.
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Drugs that boost a brain glutamate transporter to reduce alcohol dependence
Testing new compounds that increase a brain protein that clears glutamate to help people with alcohol dependence drink less and avoid relapse.
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Investigating how certain receptors affect lung inflammation
This study is looking at how certain molecules in the lungs affect inflammation and immune responses, especially in people with lung injuries or breathing problems, to help find better treatments for these conditions.
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Investigating how UV radiation affects skin cells and their protective responses
This study is looking at how UV rays from the sun can harm skin cells and lead to melanoma, a serious skin cancer, and it’s exploring how a specific protein called BRG1 helps skin cells respond to that damage, which could help us find better ways to protect against skin cancer.
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Targeting a specific enzyme to improve treatment for triple-negative breast cancer
This study is looking at how a protein called fatty acid synthase (FASN) affects triple-negative breast cancer and whether blocking it can help make treatments like PARP inhibitors work better, with the hope of finding safer and more effective options for patients.
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Investigating the effects of pesticide exposure on autism risk using prairie voles
This study is looking at how being around certain pesticides while growing up might affect the chances of developing autism and other learning challenges in kids, using prairie voles to help understand the potential risks for humans.
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Understanding how stress affects hormone release in the adrenal medulla
This study looks at how your body’s stress response works, especially how certain nerve signals help release hormones from special cells when you're stressed, to better understand how different types of stress can affect your health and how you manage stress.
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How changes in tRNA affect aging processes
This study is looking at how changes in a special type of molecule called tRNA, which helps make proteins in our cells, might affect how we age and contribute to diseases like heart problems, diabetes, and cancer, especially when our cells are under stress.
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Investigating how neutrophil extracellular traps affect inflammatory bowel disease
This study is looking at how a certain enzyme affects the immune response in people with inflammatory bowel disease (IBD), like Crohn's Disease and Ulcerative Colitis, to help find new ways to improve gut health and treatment options.
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