How aging affects bone cell energy and function
PPARG regulates osteocyte bioenergetics and function during aging
['FUNDING_R01'] · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · NIH-11103148
This study is looking at how a protein called PPARG affects the energy and health of bone cells as we get older, with the goal of finding ways to keep our bones strong and healthy as we age.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS (nih funded) |
| Locations | 1 site (TOLEDO, UNITED STATES) |
| Trial ID | NIH-11103148 on ClinicalTrials.gov |
What this research studies
This research investigates the role of a specific protein, PPARG, in regulating the energy metabolism and function of bone cells called osteocytes as people age. It aims to understand how changes in PPARG activity influence bone health and energy levels, potentially leading to conditions like fractures and diabetes. The study will use various mouse models and advanced techniques to explore the relationship between aging, energy metabolism, and bone remodeling. By uncovering these connections, the research seeks to provide insights into how to maintain bone health in older adults.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing age-related bone loss or those at risk of fractures.
Not a fit: Patients who are younger and do not have any issues related to bone health or metabolism may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing age-related bone loss and associated health issues in older adults.
How similar studies have performed: Previous research has shown promising results in understanding the role of energy metabolism in bone health, making this approach both relevant and potentially impactful.
Where this research is happening
TOLEDO, UNITED STATES
- UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS — TOLEDO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LECKA-CZERNIK, BEATA ANNA — UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS
- Study coordinator: LECKA-CZERNIK, BEATA ANNA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.