How aging affects bone cell energy and function
Official title: PPARG regulates osteocyte bioenergetics and function during aging
Funded at University of Toledo Health Sci Campus · NIH-11103148 · Data updated 2026-11-12
This study is looking at how a protein called PPARG affects the energy and health of bone cells as we get older, with the goal of finding ways to keep our bones strong and healthy as we age.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Toledo Health Sci Campus NIH-funded |
| Lab location | 1 site (Toledo, United States) |
| Project start | September 30, 2021 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $668,560 |
| NIH project number | 5R01AG071332-05 |
| Project ID | NIH-11103148 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing age-related bone loss or those at risk of fractures.
✕Less likely to help
Patients who are younger and do not have any issues related to bone health or metabolism may not benefit from this research.
What this research studies
This research investigates the role of a specific protein, PPARG, in regulating the energy metabolism and function of bone cells called osteocytes as people age. It aims to understand how changes in PPARG activity influence bone health and energy levels, potentially leading to conditions like fractures and diabetes. The study will use various mouse models and advanced techniques to explore the relationship between aging, energy metabolism, and bone remodeling. By uncovering these connections, the research seeks to provide insights into how to maintain bone health in older adults.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing age-related bone loss and associated health issues in older adults.
How similar studies have gone: Previous research has shown promising results in understanding the role of energy metabolism in bone health, making this approach both relevant and potentially impactful.
Where this research is happening
-
University of Toledo Health Sci Campus
Toledo, United States Active
Researchers
- Principal investigator: Lecka-Czernik, Beata Anna — University of Toledo Health Sci Campus
- Study coordinator: Lecka-Czernik, Beata Anna
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.