Understanding the complex protein networks involved in Alzheimer's dementia.
Official title: Investigation of active kinome networks in Alzheimer's dementia.
Funded at University of Toledo Health Sci Campus · NIH-11190905 · Data updated 2026-11-12
This study is looking at how certain proteins work together in the brain to help us understand Alzheimer's better, with the hope of finding new ways to treat this challenging disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Toledo Health Sci Campus NIH-funded |
| Lab location | 1 site (Toledo, United States) |
| Project start | September 15, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $681,233 |
| NIH project number | 5R01AG083628-02 |
| Project ID | NIH-11190905 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's dementia or those at risk of developing the condition.
✕Less likely to help
Patients with other forms of dementia unrelated to Alzheimer's may not benefit from this research.
What this research studies
This research investigates the intricate protein interactions that contribute to Alzheimer's dementia. By focusing on protein function rather than just gene expression, the team aims to uncover how these proteins interact and affect the progression of the disease. Utilizing advanced techniques, they will explore the non-linear networks of protein kinases, which are crucial for understanding the underlying mechanisms of Alzheimer's. The goal is to generate new insights that could lead to more effective treatments for this debilitating condition.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding and treating Alzheimer's dementia.
How similar studies have gone: While the approach of investigating protein networks is gaining traction, this specific focus on non-linear kinase signaling in Alzheimer's is relatively novel.
Where this research is happening
-
University of Toledo Health Sci Campus
Toledo, United States Active
Researchers
- Principal investigator: Mccullumsmith, Robert E — University of Toledo Health Sci Campus
- Study coordinator: Mccullumsmith, Robert E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.