Understanding the complex protein networks involved in Alzheimer's dementia.
Investigation of active kinome networks in Alzheimer's dementia.
This study is looking at how certain proteins work together in the brain to help us understand Alzheimer's better, with the hope of finding new ways to treat this challenging disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Toledo Health Sci Campus NIH-funded |
| Lab location | 1 site (Toledo, United States) |
| Project ID | NIH-11190905 on NIH RePORTER |
What this research studies
This research investigates the intricate protein interactions that contribute to Alzheimer's dementia. By focusing on protein function rather than just gene expression, the team aims to uncover how these proteins interact and affect the progression of the disease. Utilizing advanced techniques, they will explore the non-linear networks of protein kinases, which are crucial for understanding the underlying mechanisms of Alzheimer's. The goal is to generate new insights that could lead to more effective treatments for this debilitating condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's dementia or those at risk of developing the condition.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding and treating Alzheimer's dementia.
How similar studies have performed: While the approach of investigating protein networks is gaining traction, this specific focus on non-linear kinase signaling in Alzheimer's is relatively novel.
Where this research is happening
Toledo, United States
- University of Toledo Health Sci Campus — Toledo, United States (Active)
Researchers
- Principal investigator: Mccullumsmith, Robert E — University of Toledo Health Sci Campus
- Study coordinator: Mccullumsmith, Robert E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.