Kidney health panel to guide blood pressure treatment in resistant hypertension
Official title: Building a kidney monitoring panel to guide therapy in resistant hypertension
Funded at University of Toledo Health Sci Campus · NIH-11380644 · Data updated 2026-11-12
A study to test a urine-based kidney health panel that helps doctors tell the difference between real kidney injury and normal kidney changes when treating people with resistant high blood pressure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Toledo Health Sci Campus NIH-funded |
| Lab location | 1 site (Toledo, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $647,077 |
| NIH project number | 5R01HL175306-03 |
| Project ID | NIH-11380644 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults 21 years and older with resistant hypertension and related kidney concerns who are under active follow-up.
✕Less likely to help
Patients without resistant hypertension or kidney-related issues may not benefit from this panel.
What this research studies
This project aims to create a urine test panel (KTHP) that indicates kidney tubule health and helps clinicians decide whether changes in creatinine during high blood pressure treatment are worrisome or benign. By focusing on patients with resistant hypertension and suspected renal artery issues, the study seeks to predict how much blood pressure will drop when medications are adjusted. If successful, the panel could reduce unnecessary stopping of effective therapy and improve kidney and heart outcomes. The research will involve measuring biomarkers in urine and correlating them with treatment responses and kidney function changes.
Why it matters
Potential benefit: If successful, patients could receive safer, more effective blood pressure management with fewer unnecessary medication changes.
How similar studies have gone: Previous work shows that urine biomarkers can reflect kidney health and treatment responses, supporting this approach but the panel is a novel combination for this specific context.
Where this research is happening
-
University of Toledo Health Sci Campus
Toledo, United States Active
Researchers
- Principal investigator: Gupta, Rajesh — University of Toledo Health Sci Campus
- Study coordinator: Gupta, Rajesh
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.