Understanding how active protein kinases drive Alzheimer’s dementia
Official title: Investigation of active kinome networks in Alzheimer's dementia.
Funded at University of Toledo Health Sci Campus · NIH-11332916 · Data updated 2026-11-12
A team is studying how the activity of protein kinases affects the progression of Alzheimer’s dementia using advanced protein-focused methods.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Toledo Health Sci Campus NIH-funded |
| Lab location | 1 site (Toledo, United States) |
| Project start | September 15, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $736,899 |
| NIH project number | 5R01AG083628-03 |
| Project ID | NIH-11332916 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with Alzheimer’s dementia or related cognitive disorders who may benefit from future kinase-targeted therapies.
✕Less likely to help
Participants with advanced disease where kinase pathways are no longer modifiable may see limited direct benefit.
What this research studies
This project uses multi-omics and protein-function measurements to explore how kinase signaling networks change as Alzheimer’s progresses. By examining non-linear kinase activity and network interactions, researchers aim to uncover mechanisms behind brain dysfunction in AD. The study emphasizes measuring protein function rather than just gene expression to gain a deeper view of disease biology. Results could inform future therapies that target kinase pathways involved in AD pathology.
Why it matters
Potential benefit: If successful, findings could guide new therapeutic targets and strategies to slow or modify Alzheimer’s progression.
How similar studies have gone: Previous work shows kinase signaling can be linked to neurodegenerative processes, but the non-linear networks explored here are relatively novel.
Where this research is happening
-
University of Toledo Health Sci Campus
Toledo, United States Active
Researchers
- Principal investigator: Mccullumsmith, Robert E — University of Toledo Health Sci Campus
- Study coordinator: Mccullumsmith, Robert E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.