Understanding how stress affects hormone release in the adrenal medulla
Official title: Pre and post-synaptic pathways underlying the stress response in the adrenal medulla
Funded at University of Toledo Health Sci Campus · NIH-11039917 · Data updated 2026-11-12
This study looks at how your body’s stress response works, especially how certain nerve signals help release hormones from special cells when you're stressed, to better understand how different types of stress can affect your health and how you manage stress.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Toledo Health Sci Campus NIH-funded |
| Lab location | 1 site (Toledo, United States) |
| Project start | March 1, 2022 |
| Project end | February 28, 2026 |
| Funding year | 2025 |
| Award (this year) | $370,154 |
| NIH project number | 5R01NS122534-10 |
| Project ID | NIH-11039917 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals experiencing chronic stress or stress-related health issues.
✕Less likely to help
Patients with no history of stress-related conditions or those not experiencing significant stress may not receive benefit from this research.
What this research studies
This research investigates the mechanisms by which the adrenal medulla responds to stress, focusing on how specific nerve signals influence hormone release. It examines the role of chromaffin cells, which are responsible for releasing hormones during stress, and how they are activated by nerve inputs. By studying the pathways involved in this process, the research aims to clarify how different stressors can lead to varying hormonal responses, which could impact overall health and stress management.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for stress-related disorders by enhancing our understanding of hormonal regulation during stress.
How similar studies have gone: Previous research has shown success in understanding stress responses through similar biological pathways, indicating that this approach is grounded in established science.
Where this research is happening
-
University of Toledo Health Sci Campus
Toledo, United States Active
Researchers
- Principal investigator: Anantharam, Arun — University of Toledo Health Sci Campus
- Study coordinator: Anantharam, Arun
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.