Investigating how neutrophil extracellular traps affect inflammatory bowel disease

Who could benefit from this research

What this research studies

This research focuses on understanding the role of neutrophil extracellular traps (NETs) in inflammatory bowel disease (IBD), which includes conditions like Crohn’s Disease and Ulcerative Colitis. The study will explore how a specific enzyme, peptidyl arginine deiminase-4 (PAD4), influences the release of NETs and their impact on gut health. By using murine models, the research aims to uncover the molecular mechanisms behind PAD4's role in inflammation and tissue repair in the gastrointestinal tract. Patients may benefit from insights that could lead to new therapeutic strategies for managing IBD.

Why it matters

Where this research is happening

• University of Toledo Health Sci Campus
  Toledo, United States Active

Researchers

• Principal investigator: Vijay-Kumar, Matam — University of Toledo Health Sci Campus
• Study coordinator: Vijay-Kumar, Matam

Related research

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.