Investigating how neutrophil extracellular traps affect inflammatory bowel disease
Role of neutrophil extracellular traps (NETs) in Inflammatory bowel disease
This study is looking at how a certain enzyme affects the immune response in people with inflammatory bowel disease (IBD), like Crohn's Disease and Ulcerative Colitis, to help find new ways to improve gut health and treatment options.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Toledo Health Sci Campus NIH-funded |
| Lab location | 1 site (Toledo, United States) |
| Project ID | NIH-11019711 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of neutrophil extracellular traps (NETs) in inflammatory bowel disease (IBD), which includes conditions like Crohn’s Disease and Ulcerative Colitis. The study will explore how a specific enzyme, peptidyl arginine deiminase-4 (PAD4), influences the release of NETs and their impact on gut health. By using murine models, the research aims to uncover the molecular mechanisms behind PAD4's role in inflammation and tissue repair in the gastrointestinal tract. Patients may benefit from insights that could lead to new therapeutic strategies for managing IBD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with inflammatory bowel disease, including Crohn’s Disease and Ulcerative Colitis.
Not a fit: Patients with other gastrointestinal disorders not classified as inflammatory bowel disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve the management of inflammatory bowel disease.
How similar studies have performed: While the role of NETs in inflammation is being explored, this specific investigation into PAD4's function in IBD is relatively novel and has not been extensively tested.
Where this research is happening
Toledo, United States
- University of Toledo Health Sci Campus — Toledo, United States (Active)
Researchers
- Principal investigator: Vijay-Kumar, Matam — University of Toledo Health Sci Campus
- Study coordinator: Vijay-Kumar, Matam
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.