Investigating how certain receptors affect lung inflammation
Official title: Novel cysteinyl leukotriene receptor signaling in regulating cellular, and molecular events in lung inflammation
Funded at University of Toledo Health Sci Campus · NIH-11094560 · Data updated 2026-11-12
This study is looking at how certain molecules in the lungs affect inflammation and immune responses, especially in people with lung injuries or breathing problems, to help find better treatments for these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Toledo Health Sci Campus NIH-funded |
| Lab location | 1 site (Toledo, United States) |
| Project start | June 9, 2025 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $579,309 |
| NIH project number | 1R01HL178459-01 |
| Project ID | NIH-11094560 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults experiencing acute lung injury or respiratory distress syndromes.
✕Less likely to help
Patients with chronic lung conditions unrelated to acute inflammation may not benefit from this research.
What this research studies
This research focuses on understanding the role of cysteinyl leukotrienes and their receptors in lung inflammation, particularly in conditions like acute lung injury and respiratory distress. The researchers will explore how these receptors influence the behavior of immune cells called macrophages, which play a crucial role in inflammation. By conducting experiments both in the lab and in animal models, they aim to uncover the mechanisms by which these receptors regulate inflammation and immune responses in the lungs. This could lead to new insights into treating respiratory conditions.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for patients suffering from acute lung injuries and related respiratory conditions.
How similar studies have gone: Previous research has shown promising results in understanding the role of leukotriene receptors in inflammation, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Toledo Health Sci Campus
Toledo, United States Active
Researchers
- Principal investigator: Paruchuri, Sailaja — University of Toledo Health Sci Campus
- Study coordinator: Paruchuri, Sailaja
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.